Lung injury score (LIS)—median (Q1; Q3) |
|---|
| | Control | Intervention | P value |
|---|
Entire lung | 0.27 (0.23; 0.28) | 0.53 (0.51; 0.58) | 0.0025 |
Apical lung | 0.24 (0.16; 0.27) | 0.52 (0.32; 0.60) | 0.0023 |
Central lung | 0.24 (0.15; 0.39) | 0.50 (0.29; 0.59) | 0.0047 |
Basal lung | 0.33 (0.18; 0.46) | 0.59 (0.46; 0.70) | 0.001 |
- Lung injury was assessed correspondingly to Matute Bello et al.—using a semi-quantitative weighted lung injury scoring (LIS) that contained the following parameters: (i) neutrophils in alveolar space, (ii) neutrophils in interstitial space, (iii) hyaline membranes, (iv) protein detritus in alveolar space, and (v) septum thickening. LIS was calculated as follows: [20 × (i) + 14 × (ii) + 7 × (iii) + 7 × (iv) + 2 × (v)]/100—resulting in values from 0 to 1, where 1 represents maximal lung damage. Results are presented for the different lung regions of interest (allocation) investigated and summarized for the entire lung. Measures are given as median and 25% and 75% quartile (Q1; Q3). P value: Wilcoxon signed-rank test
