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Table 1 Respiration, hemodynamic, and oxygenation parameters

From: PO2 oscillations induce lung injury and inflammation

Measurement time point

Control (constant PO2)

Intervention (cyclic PO2)

BLH

BL-ECMO

ECMO 6

BLH

BL-ECMO

ECMO 6

Respiration

 RR (per min)

22 ± 4

20

20

23 ± 3

20

20

 VT (mL/kg)

6.2 ± 0.4

2

2

6.1 ± 0.3

2

2

 PEEP/CPAP (cm H2O)

5 ± 1

15

15

5 ± 1

15

15

 I to E ratio

1:1

1:1

1:1

1:1

1:1

1:1

 FIO2

0.3

0.4

0.4

0.3

0.4

0.4

vv-ECMO

 ECMO-blood flow (L/min)

NA

3.6 ± 0.2

3.7 ± 0.4

NA

3.5 ± 0.1

3.8 ± 0.5

 Sweep gas flow (L/min)

NA

4.4 ± 0.8

4.8 ± 0.8

NA

3.9 ± 0.9

4 ± 0.6

 FO2 oxygenator

NA

60.7 ± 13.1

56.5 ± 7.9

NA

1–100

1–100

Hemodynamics

 HR (per min)

95 ± 13

111 ± 6

103 ± 6

99 ± 11

100 ± 12

103 ± 16

 MAP (mm Hg)

80.5 ± 9.6

84.3 ± 8.3

79.1 ± 11.7

83.2 ± 8.3

75 ± 9.9

79.3 ± 7.5

 MPAP (mm Hg)

21.2 ± 1.6

22.9 ± 2.7

21.8 ± 3

20.4 ± 2.4

22.5 ± 3.4

23 ± 3.8

 CVP (mm Hg)

12 ± 2

12 ± 2

12 ± 3

12 ± 2

13 ± 1

11 ± 2

 CO (L/min)

5.5 ± 1.2

5.8 ± 0.6

5.1 ± 0.9

5.2 ± 0.5

5.1 ± 1

4.6 ± 0.6

Oxygenation

 PaCO2 (Torr)

40.2 ± 6.4

51.9 ± 11.1

55.8 ± 3.9

38.8 ± 4.6

47.8 ± 6.9

52.1 ± 4.1

 Mean PaO2 (Torr)

175.3 ± 19.6

105.3 ± 4.8

102.6 ± 2.8

162.7 ± 22.8

106.2 ± 7.8

102 ± 2.6

 ΔPaO2 (Torr)*

4.1 ± 1.8

3.5 ± 1.6

2.3 ± 1.3

4.4 ± 2.4

30.5 ± 6.8

27 ± 9.4

 Mean SmvO2 (%)

69.4 ± 6.6

66.3 ± 2.8

66 ± 3.4

66.2 ± 7.1

67.4 ± 3

69 ± 2.7

 ΔSmvO2 (%) *

3 ± 1.6

2.4 ± 1.1

1.6 ± 0.9

3 ± 0.8

38.5 ± 7.2

40.9 ± 4.3

 PmvO2 (Torr)

44.7 ± 5.5

44.9 ± 2.5

42.1 ± 2.3

42.9 ± 6

42.6 ± 5.4

48.1 ± 6.2

 SpO2 (%)

99 ± 1

99 ± 1

99 ± 1

99 ± 1

99 ± 1

99 ± 1

Clinical chemistry

 Hemoglobin (g/dL)

NA

8.9 ± 0.9

7.3 ± 1

NA

9.0 ± 0.7

7.8 ± 0.5

 Red blood cells (T/L)

NA

5.9 ± 0.8

4.5 ± 0.4

NA

5.5 ± 0.3

4.8 ± 0.3

 White blood cells (G/L)

NA

24 ± 4.7

20.3 ± 5.4

NA

26.5 ± 7.2

23.1 ± 0.3

 Platelets (G/L)

NA

347 ± 89

264 ± 72

NA

330 ± 173

233 ± 135

  1. Presented are the results of respiration and vvECMO settings, hemodynamics and oxygenation parameters and clinical chemistry (blood count) data. Values are given as mean and standard deviation, itemized for the control group (constant PO2) and the intervention group (cyclic PO2) for the measurement time points of baseline healthy (BLH), after vvECMO installation (BL-ECMO), and after 6 h of the experimental time (ECMO 6). Descriptive statistics to point out differences between the groups: generalized linear model analysis for repeated measures
  2. RR respiratory rate, VT tidal volume, PEEP positive end-expiratory pressure, CPAP continuous positive airway pressure, I to E ratio inspiration to expiration ratio, FIO2 fraction of inspired oxygen, vv-ECMO vevo-venous extracorporeal membrane oxygenation, HR heart rate, MAP mean arterial pressure, MPAP mean pulmonary artery pressure, CVP central venous pressure, CO cardiac output, PaCO2 arterial partial pressure of carbon dioxide, PaO2 arterial partial pressure of oxygen, ΔPaO2 oscillation amplitude in PaO2, SmvO2 mixed venous oxygen saturation, ΔSmvO2 oscillation amplitude in SmvO2, PmvO2 mixed venous partial pressure of oxygen, SpO2 peripheral capillary oxygen saturation
  3. *P < 0.001
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Critical Care

ISSN: 1364-8535