Table 3 Pharmacological agents associated with 90-day mortality
Variable | Unadjusted model | p value | Adjusted model | p value |
|---|---|---|---|---|
Age | 1.62 (1.36–1.93) | < 0.001 | 1.34 (1.10–1.62) | < 0.001 |
Sex (males are reference) | 0.94 (0.76–1.17) | 0.59 | 0.93 (0.74–1.18) | 0.55 |
APACHE III | 2.24 (1.90–2.64) | < 0.001 | 2.17 (1.80–2.60) | < 0.001 |
Use of antipsychotics | 0.31 (0.23–0.42) | < 0.001 | 0.31 (0.22–0.44) | < 0.001 |
Cumulative dose of benzodiazepines | 1.07 (0.98–1.16) | 0.12 | 1.41 (1.12–1.77) | < 0.01 |
Cumulative dose of opioids | 1.01 (0.93–1.10) | 0.77 | 0.82 (0.64–1.05) | 0.12 |
Hospital site 1 (reference) | 1.00 | 1.00 | 1.00 | |
Hospital site 2 | 0.70 (0.52–0.96) | 0.03 | 0.63 (0.45–0.89) | 0.01 |
Hospital site 3 | 0.66 (0.47–0.93) | 0.02 | 0.84 (0.58–1.22) | 0.36 |
Hospital site 4 | 0.58 (0.43–0.78) | < 0.001 | 0.74 (0.54–1.01) | 0.06 |
Hospital site 5 | 1.35 (0.89–2.06) | 0.16 | 0.61 (0.38–0.99) | 0.04 |