Skip to main content
Fig. 1 | Critical Care

Fig. 1

From: Trial sequential analysis suggested the potential overestimated effect of carbonic anhydrase inhibitor for respiratory failure and metabolic alkalosis

Fig. 1

Trial sequential analysis (TSA) of 5 trials testing the effect of CAI therapy on PaCO2 in patients with respiratory failure and metabolic alkalosis. TSA of 5 trials (black square fill icons) showing that the line of cumulative Z-curve crossed the conventional boundary for benefit, but not the lines of the trial sequential monitoring boundary for benefit and required information size (RIS), which establish inconclusive evidence and suggest that further trials are needed. (X-axis, number of patients; Y-axis, cumulative Z-score; horizontal green dotted lines, conventional boundaries for benefit or harm; sloping full red lines with black square fill icons, trial sequential monitoring boundaries for benefit or harm; full blue line with black square fill icons, Z-curve; vertical red full line, required information size boundary)

Back to article page

Critical Care

ISSN: 1364-8535