Fig. 1From: Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’Anesthésie et Réanimation—SFAR)Simulated plasma concentrations obtained for a 12 g piperacillin daily dose delivered as intermittent administrations (IA, right) or continuous infusion without (CI, left) or with a loading dose (Bolus+CI, middle). The continuous infusion preceded by a loading dose is the regimen that achieves the greatest % fT ≥ MIC. The trough concentration before the next injection falls below the MIC in the discontinuous administration regimen, while the concentration may remain below the MIC for several hours after the beginning of the infusion in the case of continuous administration without a loading dose.Back to article page