Organ system network analysis and biological stability in critically ill patients

Table 1 Baseline characteristics of the patients

Variable	Non-survivors	Total survivors			Matched survivors
	(N = 91)	(N = 479)			(N = 91)
			P value^b	Cohen’s d^b		P value^c	Cohen’s d^c
Age (years)	66 (54–77)^a	64 (52–73)	0.12	0.21	68 (58–76)	0.88	0.04
Male, no. (%)	59 (65)	295 (62)	0.56		63 (69)	0.53
Cause for ICU admission, no. (%)			< 0.001			0.20
Neurological	12 (13)	123 (26)			10 (11)
Respiratory	16 (18)	22 (5)			7 (8)
Cardiovascular	11 (12)	63 (13)			16 (18)
Hepatic	4 (4)	33 (7)			7 (8)
Renal	7 (8)	11 (2)			2 (2)
Infection	18 (20)	73 (15)			21 (23)
Abdominal	7 (8)	53 (11)			12 (13)
Others	16 (18)	101 (21)			16 (18)
Sepsis, no. (%)	47 (52)	135 (28)	< 0.001		36 (40)	0.17
Surgical, no. (%)	10 (11)	206 (43)	< 0.001		30 (33)	< 0.001
Hypotension, no. (%)	52 (57)	159 (33)	< 0.001		47 (52)	0.55
APACHE II score	24 (20–30)	17 (13–22)	< 0.001	0.92	19 (14–25)	< 0.001	0.54
SOFA score	9 (6–13)	6 (4–9)	< 0.001	0.82	8 (6–12)	0.12	0.20
PaO₂/F_IO₂	206 (130–331)	324 (217–440)	< 0.001	0.67	214 (134–353)	0.51	0.07
Blood lactate (mmol/L)	2.3 (1.3–4.9)	1.7 (1.0–2.8)	< 0.001	0.55	2.3 (1.2–3.9)	0.44	0.15
Plasma NGAL (ng/mL)	231 (110–518)	114 (60–309)	< 0.001	0.33	188 (84–439)	0.43	0.02
Total bilirubin (mg/dL)	0.9 (0.6–2.0)	0.7 (0.5–1.3)	0.02	0.29	0.9 (0.6–1.8)	0.95	0.19
Platelet count (× 10⁴/μL)	11.0 (4.7–23.1)	18.3 (11.9–24.5)	< 0.001	0.50	14.1 (8.2–18.8)	0.60	0.06
C-reactive protein (mg/dL)	6.4 (0.9–18.5)	1.6 (0.3–8.9)	< 0.001	0.47	3.2 (0.6–12.6)	0.15	0.19

^aValues denote the number of patients (percentage) or median (interquartile range)
^bComparing total survivors to non-survivors
^cComparing matched survivors to non-survivors

ISSN: 1364-8535