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Table 1 The characteristics of included studies

From: The effects and safety of vasopressin receptor agonists in patients with septic shock: a meta-analysis and trial sequential analysis

Study Year No. of patients Patients Intervention Comparison Outcome
Malay 1999 10 Septic shock Vasopressin 0.04 U/min NE 24 h
Albanese 2005 20 Septic shock Terlipressin: one bolus of 1 mg and a second bolus of 1 mg was given if the MAP < 65 mmHg after 20 mins NE was started at a dose of 0.3 μg/kg/min, followed by 0.3 μg/kg/min increments at 4-min intervals to raise MAP to 65 to 75 mmHg Hospital
Lauzier 2006 23 Septic shock Arginine-vasopressin 0.04–0.20 U/min NE 0.1–2.8 μg/kg/min ICU
Russell 2008 799 Septic shock Vasopressin 0.01–0.03 U/min or at clinician’s discretion NE 5 to 15 mg/min or at clinician’s discretion 90 days
Acevedo 2009 24 Septic shock and cirrhosis Terlipressin 1–2 mg/4 h plus alpha-adrenergic drugs Alpha-adrenergic drugs alone Hospital
Morelli 2009 45 Septic shock Terlipressin 1.3 μg/kg/h
Vasopressin 0.03 U/min
NE 15 μg/min ICU
Han 2012 139 Septic shock Pituitrin 1.0–2.5 U/h Dopamine or NE 2–20 μg/kg/h 28 days
Svoboda 2012 30 Septic shock Terlipressin 4 mg/24 h for 72 h plus open-label norepinephrine NE > 0.6 μg/kg/min for more than 24 h 28 days
Fonseca Ruiz 2013 30 Septic shock Vasopressin 0.01–0.04 U/min plus NE NE 28 days
Hua 2013 32 Septic shock patients with ARDS Terlipressin 1.3 mg/kg/h Dopamine < 20 mg/kg/min 28 days
Oliveira 2014 387 Septic shock Vasopressin 0.01–0.03 U/min with low doses of norepinephrine NE 0.05–2.0 μg/kg/min 28 days
Barzegar 2016 30 Septic shock Vasopressin 0.03 μg/min plus NE NE: infusion adjusted to MAP ≥ 65 mmHg 28 days
Choudhury 2016 84 Cirrhotics with septic shock Terlipressin 2–8 mg over 24 h NE 7.5–60 μg/min 28 days
Clem 2016 82 Septic shock Vasopressin 0.04 U/min plus NE with 0.05–0.5 μg/kg/min NE 0.05 to 0.5 μg/kg/min 28 days
Gordon 2016 408 Septic shock Vasopressin: titrated up to 0.06 U/min to maintain the MAP 65 to 75 mmHg NE: titrated up to 12 μg/min to maintain the MAP 65 to 75 mmHg 28 days
Capoletto 2017 250 Septic shock and cancer Vasopressin NE 90 days
Chen 2017 57 Septic shock patients with ARDS Terlipressin 0.01–0.04 U/min to maintain MAP between 65 and 75 mmHg, if necessary plus NE NE > 1 μg/min to maintain MAP between 65 and 75 mmHg 28 days
Prakash 2017 184 Cirrhosis with septic shock. Terlipressin 2 mg/24 h and 3.75–30 μg/min of NE as needed to maintain MAP > 65 mmHg NE 7.5–60 μg/min 30 days
Russell 2017 48 Septic shock Selepressin 1.25, 2.5, and 3.75 ng/kg/min until shock resolution or a maximum of 7 days Placebo 28 days
Liu 2018 535 Septic shock Terlipressin 20–160 μg/h NE 4–30 μg/min 28 days
  1. No number, NE norepinephrine, ICU intensive care unit, ARDS acute respiratory distress syndrome