Skip to main content
Fig. 2 (abstract P004). | Critical Care

Fig. 2 (abstract P004).

From: 39th International Symposium on Intensive Care and Emergency Medicine

Fig. 2 (abstract P004).

TGF-β secreted by MSCs regulated the M1 to M2 in LPS-Stimulated RAW264.7. LPS stimulated RAW264.7 co-culture with MSCs in transwell system for 24, 48 and 72 hours. (a): LPS increased the level of IL-6, whereas MSCs inhibited expression of IL-6. (b, c): MSCs reduced M1 macrophages while increased M2 macrophages in LPS stimulated RAW264.7. (d): The concentration of TGF-β was obviously increased in MSCs directed or in-directed group. (e, f, g): LPS increased IL-6 and M1 macrophages, and MSCs inhibited the IL-6 and M1 macrophages while increased M2 macrophages. TGF-βR inhibitor reversed the effect of MSCs on LPS-stimulated RAW264.7. *P<0.05, **P<0.01, *** P<0.001 compared with control group. # # # P<0.001 compared with LPS stimulated group. &&& P<0.001 compared with MSCs treatment group

Back to article page