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Table 3 Analysis of the impact of potential confounders of the autoimmune disease-30-day mortality association

From: The association between autoimmune disease and 30-day mortality among sepsis ICU patients: a cohort study

Adjusting for confounders of the association between autoimmune disease and 30-day mortality

OR (95% CI)

P value

Magnitude of confounding

No confounders adjusted (“crude”)

0.71 (0.58–0.86)

< 0.001

Age adjusted

0.74 (0.60–0.90)

0.003

− 4.46%

Sex adjusted

0.71 (0.60–0.86)

< 0.001

− 0.31%

Race adjusted

0.71 (0.58–0.87)

< 0.001

− 0.93%

Documented bacteremia adjusted

0.68 (0.56–0.83)

< 0.001

4.41%

Infection site adjusted

0.72 (0.56–0.83)

0.001

− 1.39%

SOFA score adjusted

0.81 (0.65–1.00)

0.051

− 12.34%

Elixhauser comorbidity index adjusted

0.71 (0.57–0.86)

< 0.001

0.26%

DMARD or prednisone usage adjusted

0.66 (0.54–0.81)

< 0.001

7.58%

ICU care unit adjusted

0.71 (0.58–0.86)

< 0.001

0.10%

  1. Magnitude of confounding = (ORcrude − ORadjusted)/ORadjusted
  2. OR odds ratio, CI confidence interval, SOFA Sequential Organ Failure Assessment, DMARD disease-modifying antirheumatic drug, ICU intensive care unit