Skip to main content

Table 3 Potential outcome measures by treatment group

From: Permissive versus restrictive temperature thresholds in critically ill children with fever and infection: a multicentre randomized clinical pilot trial

Potential outcome measures Permissive (N = 38) Restrictive (N = 49) Effect estimate (95% CI)
PICU mortality, n/N (%) 1/37 (2.7) 1/49 (2.0) 1.3 (0.1, 20.5)a − 0.7 (− 7.2, 5.9)b
Hospital mortality, n/N (%) 1/36 (2.8) 2/46 (4.3) 0.6 (0.1, 6.8)a 1.6 (− 6.4, 9.5)b
30-day mortality, n/N (%) 2/37 (5.4) 1/49 (2.0) 2.6 (0.2, 28.1)a − 3.4 (− 11.7, 4.9)b
Length of stay in PICU (days)
All patients N = 37 N = 49   
 Mean (SD) 7.3 (4.3) 8.1 (8.6)   
 Median (IQR) 6 (4, 10) 6 (4, 8)   
Survivors to PICU discharge N = 36 N = 48   
 Mean (SD) 7.2 (4.3) 7.9 (8.5)   
 Median (IQR) 6 (4, 9) 6 (4, 8)   
Receipt and duration of organ supportc
Mechanical ventilation, n (%) 38 (100) 49 (100)   
 Median (IQR) 5 (3, 8) 5 (3, 7)  
 Mean (SD) 6.5 (4.6) 6.2 (5.5) 0.3 (− 1.8, 2.5)d
Cardiovascular support, n (%) 8 (21.1) 13 (26.5)   
 Median (IQR) 2 (2, 3) 3 (2, 6)  
 Mean (SD) 0.5 (1.1) 1.2 (2.9) − 0.7 (− 1.6, 0.2)d
Renal support, n (%) 1 (2.6) 3 (6.1)   
 Mean (SD) 0.4 (2.4) 0.3 (1.6) 0.1 (− 0.8, 1.0)d
 Median (IQR) N < 5 N < 5   
Days alive and free (to 28 days) from
 PICU, mean (SD) [N] 19.8 (6.4) [37] 20.4 (6.2) [49] − 0.7 (− 3.4, 2.1)d
 Mechanical ventilation, mean (SD) 20.5 (6.7) [38] 21.6 (6.1) [49] − 1.1 (− 3.8, 1.7)d
  1. SD standard deviation, IQR interquartile range, CI confidence interval
  2. aRisk ratio
  3. bAbsolute risk reduction
  4. cMean and standard deviation reported for all patients, median and interquartile range reported for patients receiving the organ support only (where at least five patients in each group received the support)
  5. dMean difference