Table 3 Potential outcome measures by treatment group
Potential outcome measures | Permissive (N = 38) | Restrictive (N = 49) | Effect estimate (95% CI) | |
|---|---|---|---|---|
PICU mortality, n/N (%) | 1/37 (2.7) | 1/49 (2.0) | 1.3 (0.1, 20.5)a | − 0.7 (− 7.2, 5.9)b |
Hospital mortality, n/N (%) | 1/36 (2.8) | 2/46 (4.3) | 0.6 (0.1, 6.8)a | 1.6 (− 6.4, 9.5)b |
30-day mortality, n/N (%) | 2/37 (5.4) | 1/49 (2.0) | 2.6 (0.2, 28.1)a | − 3.4 (− 11.7, 4.9)b |
Length of stay in PICU (days) | ||||
All patients | N = 37 | N = 49 | ||
Mean (SD) | 7.3 (4.3) | 8.1 (8.6) | ||
Median (IQR) | 6 (4, 10) | 6 (4, 8) | ||
Survivors to PICU discharge | N = 36 | N = 48 | ||
Mean (SD) | 7.2 (4.3) | 7.9 (8.5) | ||
Median (IQR) | 6 (4, 9) | 6 (4, 8) | ||
Receipt and duration of organ supportc | ||||
Mechanical ventilation, n (%) | 38 (100) | 49 (100) | ||
Median (IQR) | 5 (3, 8) | 5 (3, 7) | ||
Mean (SD) | 6.5 (4.6) | 6.2 (5.5) | 0.3 (− 1.8, 2.5)d | |
Cardiovascular support, n (%) | 8 (21.1) | 13 (26.5) | ||
Median (IQR) | 2 (2, 3) | 3 (2, 6) | ||
Mean (SD) | 0.5 (1.1) | 1.2 (2.9) | − 0.7 (− 1.6, 0.2)d | |
Renal support, n (%) | 1 (2.6) | 3 (6.1) | ||
Mean (SD) | 0.4 (2.4) | 0.3 (1.6) | 0.1 (− 0.8, 1.0)d | |
Median (IQR) | N < 5 | N < 5 | ||
Days alive and free (to 28 days) from | ||||
PICU, mean (SD) [N] | 19.8 (6.4) [37] | 20.4 (6.2) [49] | − 0.7 (− 3.4, 2.1)d | |
Mechanical ventilation, mean (SD) | 20.5 (6.7) [38] | 21.6 (6.1) [49] | − 1.1 (− 3.8, 1.7)d | |