Table 1 Indications for oral anticoagulation in patients at risk of venous thromboembolism (modified from Watzke et al. 2013) [134]
Low thromboembolic risk | High thromboembolic risk |
|---|---|
Platelet inhibitors | Platelet inhibitors |
â–ª CHD or other cardiovascular diseases (cerebrovascular disease, PAD) without complications | â–ª CHD or other cardiovascular diseases with complications or additional risk factors (ischemic cardiomyopathy, St.p. cardiac decompensation, diabetes mellitus, cerebrovascular disease, PAD, renal impairment) |
â–ª Diabetes mellitus with increased cardiovascular risk | â–ª St.p. surgical or interventional procedures in patients with CHD, PAD, or cerebrovascular disease within the last year (e.g., coronary stent) |
â–ª Acute coronary syndrome or myocardial infarction during the last year | |
VKAs and NOACs | VKAs and NOACs |
▪ Non-valvular atrial fibrillation and CHADS2 score or CHADS2-VA2SC score ≤ 3 without stroke | ▪ Non-valvular atrial fibrillation and CHADS2 score or CHADS2-VA2SC score > 3 or St.p. stroke |
▪ Previous venous thromboembolism (> 3 months ago) | ▪ Atrial fibrillation |
▪ Mechanical aortic valve prosthesis without other risk factors (atrial fibrillation, cardiomyopathy, CHD, PAD, diabetes mellitus, age > 75 years, stroke) | ▪ Mechanical mitral valve prosthesis or other mechanical valve prostheses with additional risk factors, particularly atrial fibrillation or St.p. stroke |
▪ Venous thromboembolism during the last 3 months |