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Table 2 Discrimination and reclassification of combination of L-FABP and NT-proBNP for acute kidney injury

From: Authors’ response to letter “Prediction of acute kidney injury in intensive care unit patients”

  C-index P value NRI P value IDI P value
Baseline model 0.752 Ref.   Ref.   Ref.
Baseline model + NT-proBNP 0.772 0.40 0.350 < 0.001 0.016 0.002
Baseline model + L-FABP 0.797 0.06 0.615 < 0.001 0.085 < 0.001
Baseline model + NT-proBNP + L-FABP 0.806 0.02 0.630 < 0.001 0.093 < 0.001
Baseline model + NT-proBNP + L-FABP vs. Baseline model + NT-proBNP 0.034* 0.14 0.571 < 0.001 0.077 < 0.001
Baseline model + NT-proBNP + L-FABP vs. Baseline model + L-FABP 0.008* 0.73 0.230 < 0.001 0.008 0.007
  1. Baseline model included age, sex, hypertension, dyslipidemia, diabetes, smoking status, atrial fibrillation, acute decompensated heart failure, previous myocardial infarction, previous coronary revascularization, heart rate, emergent coronary angiography or percutaneous coronary intervention before admission, intraaortic balloon pump before admission, and the SOFA score
  2. IDI integrated discrimination improvement, L-FABP liver-type fatty acid-binding protein, NT-proBNP N-terminal pro-B-type natriuretic peptide, NRI net reclassification improvement, Ref. reference
  3. *Estimated differences between two groups