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Fig. 4 | Critical Care

Fig. 4

From: Thromboxane–prostaglandin receptor antagonist, terutroban, prevents neurovascular events after subarachnoid haemorrhage: a nanoSPECT study in rats

Fig. 4

NanoSPECT study of blood-brain barrier permeability (99mTc-DTPA) on day 3 and apoptosis (99mTc-Anx-V128) on day 4. a Representative image of the differential brainstem 99mTc-DTPA uptake in the SAH group (yellow arrow). Colour scales indicate signal intensities from low (blue) to high (white). NanoSPECT images (sagittal view) show the three ROIs (CH, cerebral hemispheres; CB, cerebellum; BS, brainstem). Bars indicate the mean ± SD measured in rats of sham group (n = 15), sham+TBN group (n = 5), CSF group (n = 14), SAH group (n = 15) or SAH+TBN group (n = 15). b Inter-ROI analysis of 99mTc DTPA uptake in the SAH group: predominating uptake in the infra-tentorial ROIs (CB and BS). *P < 0.05 compared to CH. c 99mTc-DTPA and d 99mTc-Anx-V128 nanoSPECT study. Results were expressed as parts per million of injected dose (ppm ID)/mm3 of tissue. Bars indicate the mean ± SD measured in rats of sham group (n = 14), sham+TBN group (n = 5), CSF group (n = 14), SAH group (n = 14) or SAH+TBN group (n = 15). *P < 0.05 compared to sham, **P < 0.05 compared to CSF, #P < 0.05 compared to sham+TBN, §P < 0.05 compared to SAH. CSF denotes cerebrospinal fluid; SAH, subarachnoid haemorrhage; TBN, terutroban; CH, cerebral hemispheres; CB, cerebellum; BS, brainstem

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