Lung fluid biomarkers for acute respiratory distress syndrome: a systematic review and meta-analysis

Table 3 Biomarkers associated with ARDS mortality

Biomarker	No. of study	No. of patients	RoM (95% CI)	p	Heterogeneity
Biomarker	No. of study	No. of patients	RoM (95% CI)	p	Q (p value)	I² (%)
Interleukin-1β	3[12, 24, 39]	137	4.617 (4.331, 4.921)	< 0.05	11.24 (0.004)	82.20
Interleukin-6	4[12, 24, 39, 41]	176	3.882 (3.270, 4.608)	< 0.05	41.09 (< 0.1)	92.70
Interleukin-8	4[24, 38, 39, 41]	160	3.679 (3.414, 3.964)	< 0.05	20.59 (< 0.1)	85.40
Kerbs von Lungren-6	2[30, 34]	65	3.178 (2.931, 3.446)	< 0.05	0.83 (0.363)	0.00
Plasminogen activator inhibitor-1	2[52, 56]	32	2.085 (2.039, 2.133)	< 0.05	1.31 (0.252)	23.70
Tumor necrosis factor-α	3[12, 24, 39]	137	1.923 (1.656, 2.233)	< 0.05	11.47 (0.003)	82.60
Procollagen peptide III	3[17, 19, 42]	194	1.714 (1.613, 1.822)	< 0.05	34.08 (< 0.1)	94.10
Total protein	3[12, 19, 42]	208	1.667 (1.595, 1.742)	< 0.05	82.47 (< 0.1)	97.60
Interleukin-2	2[13, 40]	27	0.828 (0.715, 0.959)	0.012	1.49 (0.223)	32.70
Club cell protein	2[31, 35]	37	0.406 (0.362, 0.405)	< 0.05	21.08 (< 0.1)	95.30
Interleukin-10	3[12, 24, 39]	137	1.019 (0.922, 1.127)	0.709	54.54 (< 0.1)	96.30

ISSN: 1364-8535