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Table 3 Biomarkers associated with ARDS mortality

From: Lung fluid biomarkers for acute respiratory distress syndrome: a systematic review and meta-analysis

Biomarker No. of study No. of patients RoM (95% CI) p Heterogeneity
Q (p value) I2 (%)
Interleukin-1β 3[12, 24, 39] 137 4.617 (4.331, 4.921) < 0.05 11.24 (0.004) 82.20
Interleukin-6 4[12, 24, 39, 41] 176 3.882 (3.270, 4.608) < 0.05 41.09 (< 0.1) 92.70
Interleukin-8 4[24, 38, 39, 41] 160 3.679 (3.414, 3.964) < 0.05 20.59 (< 0.1) 85.40
Kerbs von Lungren-6 2[30, 34] 65 3.178 (2.931, 3.446) < 0.05 0.83 (0.363) 0.00
Plasminogen activator inhibitor-1 2[52, 56] 32 2.085 (2.039, 2.133) < 0.05 1.31 (0.252) 23.70
Tumor necrosis factor-α 3[12, 24, 39] 137 1.923 (1.656, 2.233) < 0.05 11.47 (0.003) 82.60
Procollagen peptide III 3[17, 19, 42] 194 1.714 (1.613, 1.822) < 0.05 34.08 (< 0.1) 94.10
Total protein 3[12, 19, 42] 208 1.667 (1.595, 1.742) < 0.05 82.47 (< 0.1) 97.60
Interleukin-2 2[13, 40] 27 0.828 (0.715, 0.959) 0.012 1.49 (0.223) 32.70
Club cell protein 2[31, 35] 37 0.406 (0.362, 0.405) < 0.05 21.08 (< 0.1) 95.30
Interleukin-10 3[12, 24, 39] 137 1.019 (0.922, 1.127) 0.709 54.54 (< 0.1) 96.30
  1. Numbers within the square brackets were reference numbers
  2. RoM ratio of means, CI confident interval