Skip to main content

Table 2 Biomarkers associated with ARDS diagnosis

From: Lung fluid biomarkers for acute respiratory distress syndrome: a systematic review and meta-analysis

Biomarker No. of study No. of patients RoM (95% CI) p Heterogeneity
Q (p value) I2 (%)
Total phospholipases A2 activity 2[32, 47] 62 17.995 (11.381, 28.454) < 0.05 10.54 (0.001) 90.50
Total protein 5[25, 29, 32, 44, 48] 179 9.299 (7.575, 11.414) < 0.05 40.48 (< 0.1) 90.10
Albumin 5[21, 23, 27, 48, 57] 191 6.544 (4.908, 8.725) < 0.05 27.35 (< 0.1) 85.40
Plasminogen activator inhibitor-1 3[22, 52, 56] 135 5.525 (3.876, 7.877) < 0.05 3.69 (0.158) 45.8
Soluble receptor for advanced glycation end products 3[43, 58, 60] 162 4.901 (3.603, 7.673) < 0.05 31.19 (0.000) 93.6
Platelet activating factor-acetyl choline 4[32, 47,48,49] 120 4.783 (3.495, 6.545) < 0.05 71.83 (< 0.1) 95.80
Soluble TNF-α receptors II 2[28, 51] 110 3.253 (1.765, 5.993) < 0.05 4.95 (0.026) 79.80
Hepatic growth factor 2[54, 57] 144 3.199 (1.668, 6.135) < 0.05 0.02 (0.892) 0
Interleukin-8 7[18, 26, 36, 39, 46, 53, 54] 377 3.008 (2.322, 3.896) < 0.05 62.08 (< 0.1) 90.30
Soluble intercellular adhesion molecule-1 2[16, 20] 96 2.952 (1.902, 4.581) < 0.05 0.28 (0.6) 0
Procollagen peptide I 2[14, 23] 133 2.949 (1.867, 4.659) < 0.05 0.11 (0.743) 0.00
Interleukin-2 2[13, 40] 67 2.761 (1.508, 5.057) 0.001 17.34 (< 0.1) 94.20
Procollagen peptide III 6[17, 23, 26, 42, 53, 57] 195 2.328 (1.456, 3.723) < 0.05 2.81 (0.729) 0
Interleukin-6 5[18, 26, 39, 51, 55] 250 1.826 (1.170, 2.852) 0.008 9.1 (0.0059) 56
Club cell protein 3[25, 31, 35] 93 0.553 (0.369, 0.827) 0.004 3.6 (0.166) 44.40
Matrix metalloproteinases-9 2[26, 37] 43 0.548 (0.336, 0.893) 0.016 15.45 (< 0.1) 93.50
Transforming growth factor-β1 2[28, 54] 116 1.32 (0.575, 3.034) 0.513 0.93 (0.334) 0
Tumor necrosis factor-α 4[18, 28, 39, 51] 247 1.3 (0.917, 1.843) 0.14 2.97 (0.397) 0
Matrix metalloproteinases −2 2[37, 53] 52 1.066 (0.889, 1.278) 0.493 0.06 (0.814) 0
Total phospholipids 4[15, 32, 48, 49] 110 1.003 (0.862, 1.166) 0.973 34.25 (< 0.1) 91.20
Interleukin-1β 2[39, 51] 166 0.952 (0.628, 1.444) 0.817 4.23 (0.04) 76.30
Vascular endothelial growth factor 3[26, 45, 59] 194 0.812 (0.544, 1.212) 0.309 3.4 (0.183) 41.20
  1. Numbers within the square brackets were reference numbers
  2. RoM ratio of means, CI confident interval