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Table 3 Temperature analyses and outcomes of included patients, according to the methods of cooling. Data are expressed as count (%) or median (25th–75th percentiles)

From: Intravascular versus surface cooling for targeted temperature management after out-of-hospital cardiac arrest: an analysis of the TTH48 trial

 

IC (n = 218)

SFC (n = 134)

Primary outcome

 CPC 3–5 at 6 months

69 (32%)

51 (38%)

Secondary outcomes

 Mortality at 6 months

65 (29%)

43 (32%)

Adverse events

 Any adverse event

203 (93%)

118 (88%)

 Pneumonia

106 (49%)

56 (42%)

 Other infections

75 (34%)

54 (40%)

 Any bleeding

24 (11%)

16 (12%)

 RBC transfusion

20 (9%)

15 (11%)

 Seizure/myoclonus localized

27 (12%)

18 (13%)

 Seizure/myoclonus globalized

39 (18%)

25 (19%)

 Severe circulation failure

13 (6%)

15 (11%)

 Arrhythmias

105 (48%)

50 (37%)*

 Severe (VT/VF or unstable despite treatment)

21 (10%)

19 (14%)

 New cardiac arrest requiring CPR

7 (3%)

5 (4%)

 Renal replacement therapy

13 (6%)

14 (10%)

 Hyperglycemia

169 (78%)

113 (83%)

 Hypernatremia

21 (10%)

24 (18%)*

 Hypokalemia

88 (40%)

38 (28%)*

Resource use

 ICU length of stay (days)

5 [3–7]

6 [3–9]

  1. IC intravascular catheter, SFC surface cooling, RBC red blood cells. $p < 0.001; *p < 0.05; p < 0.1