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Table 4 Multivariate Cox regression for the prediction of 28-day mortality in the derivation and validation cohorts

From: The early identification of disease progression in patients with suspected infection presenting to the emergency department: a multi-centre derivation and validation study

Biomarker or clinical score

Patients (N)

Mortality (N)

LR χ2

DF

p value

C-index

HR IQR [95% CI]

Derivation cohort

 MR-proADM

1175

84

196.6

6

< 0.001

0.883

5.2 [3.9–6.9]

 PCT

1166

84

112.0

6

< 0.001

0.813

2.0 [1.6–2.5]

 Lactate

746

59

59.2

6

< 0.001

0.771

2.2 [1.6–3.0]

 CRP

1170

83

97.3

6

< 0.001

0.787

2.6 [1.7–4.0]

 SIRS

965

84

91.6

6

< 0.001

0.779

2.1 [1.4–3.0]

 SOFA

1175

84

143.3

6

< 0.001

0.840

2.9 [2.4–3.7]

 qSOFA

1175

84

117.7

6

< 0.001

0.825

2.5 [1.9–3.2]

 NEWS

1058

81

105.2

6

< 0.001

0.803

2.5 [1.8–3.4]

 CRB-65

1175

84

99.3

6

< 0.001

0.793

2.0 [1.5–2.5]

Validation cohort

 MR-proADM

896

45

114.6

6

< 0.001

0.899

3.7 [2.6–5.2]

 PCT

884

45

80.7

6

< 0.001

0.847

1.6 [1.3–2.1]

 CRP

780

42

75.2

6

< 0.001

0.837

2.4 [1.2–4.6]

  1. Age, cardiovascular, neurological, renal and malignancy comorbidities were used as adjusting variables within the multivariate derivation cohort model, and subsequently applied to the validation cohort. CI confidence interval, CRB-65 severity score for community-acquired pneumonia, CRP C-reactive protein, DF degrees of freedom, HR hazard ratio, IQR interquartile range, LR likelihood ratio, MR-proADM mid-regional proadrenomedullin, N number, NEWS National Early Warning Score, PCT procalcitonin, qSOFA quick Sequential Organ Failure Assessment, SIRS systemic inflammatory response syndrome, SOFA Sequential Organ Failure Assessment