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Table 3 Diagnostic power of scores regarding the primary endpoint

From: Sequential organ failure assessment score is an excellent operationalization of disease severity of adult patients with hospitalized community acquired pneumonia – results from the prospective observational PROGRESS study

  AUC Sensitivity Specificity max Youden-Index Cut-off P-value*
SOFA 0.95 [0.93,0.97] 0.86 [0.82,0.99] 0.88 [0.74,0.90] 0.74 4.5
IDSA/ATSmc 0.92 [0.89,0.94] 0.79 [0.78,1.00] 0.89 [0.69,0.90] 0.68 3.5 3.8 × 10−3
SCAP 0.87 [0.84,0.90] 0.88 [0.66,0.94] 0.69 [0.66,0.88] 0.56 10.5 2.4 × 10−7
SMART-COP 0.86 [0.82,0.90] 0.70 [0.66,0.96] 0.84 [0.61,0.86] 0.54 3.5 9.2 × 10−7
Halm 0.79 [0.75,0.83] 0.63 [0.60,0.99] 0.79 [0.42,0.81] 0.42 2.5 3.6 × 10−13
PSI 0.78 [0.73,0.82] 0.76 [0.67,0.85] 0.70 [0.67,0.72] 0.46 3.5 1.4 × 10− 14
CURB-65 0.77 [0.72,0.82] 0.72 [0.47,0.82] 0.69 [0.67,0.91] 0.41 1.5 2.2 × 10−14
CRB-65 0.76 [0.70,0.81] 0.55 [0.47,0.92] 0.84 [0.43,0.86] 0.39 1.5 9.5 × 10−15
SIRS 0.73 [0.68,0.78] 0.45 [0.35,0.55] 0.96 [0.95,0.97] 0.41 2.5 2.0 × 10−19
qSOFA 0.69 [0.64,0.74] 0.85 [0.78,0.92] 0.47 [0.44,0.49] 0.32 0.5 1.3 × 10−21
  1. Analysis was based on values at enrollment in PROGRESS (d0). Scores were ordered according to their AUC. In brackets, 95%-confidence intervals are shown. Sensitivity, specificity, and Youden-index correspond to the point of the ROC curve with maximum Youden-index (cut-off), highest values are boldfaced. P-values correspond to comparisons of AUCs with that for SOFA. All alternatives show significantly inferior diagnostic value