Sequential organ failure assessment score is an excellent operationalization of disease severity of adult patients with hospitalized community acquired pneumonia – results from the prospective observational PROGRESS study

Table 3 Diagnostic power of scores regarding the primary endpoint

	AUC	Sensitivity	Specificity	max Youden-Index	Cut-off	P-value*
SOFA	0.95 [0.93,0.97]	0.86 [0.82,0.99]	0.88 [0.74,0.90]	0.74	4.5	–
IDSA/ATSmc	0.92 [0.89,0.94]	0.79 [0.78,1.00]	0.89 [0.69,0.90]	0.68	3.5	3.8 × 10⁻³
SCAP	0.87 [0.84,0.90]	0.88 [0.66,0.94]	0.69 [0.66,0.88]	0.56	10.5	2.4 × 10⁻⁷
SMART-COP	0.86 [0.82,0.90]	0.70 [0.66,0.96]	0.84 [0.61,0.86]	0.54	3.5	9.2 × 10⁻⁷
Halm	0.79 [0.75,0.83]	0.63 [0.60,0.99]	0.79 [0.42,0.81]	0.42	2.5	3.6 × 10⁻¹³
PSI	0.78 [0.73,0.82]	0.76 [0.67,0.85]	0.70 [0.67,0.72]	0.46	3.5	1.4 × 10^− 14
CURB-65	0.77 [0.72,0.82]	0.72 [0.47,0.82]	0.69 [0.67,0.91]	0.41	1.5	2.2 × 10⁻¹⁴
CRB-65	0.76 [0.70,0.81]	0.55 [0.47,0.92]	0.84 [0.43,0.86]	0.39	1.5	9.5 × 10⁻¹⁵
SIRS	0.73 [0.68,0.78]	0.45 [0.35,0.55]	0.96 [0.95,0.97]	0.41	2.5	2.0 × 10⁻¹⁹
qSOFA	0.69 [0.64,0.74]	0.85 [0.78,0.92]	0.47 [0.44,0.49]	0.32	0.5	1.3 × 10⁻²¹

Analysis was based on values at enrollment in PROGRESS (d0). Scores were ordered according to their AUC. In brackets, 95%-confidence intervals are shown. Sensitivity, specificity, and Youden-index correspond to the point of the ROC curve with maximum Youden-index (cut-off), highest values are boldfaced. P-values correspond to comparisons of AUCs with that for SOFA. All alternatives show significantly inferior diagnostic value

ISSN: 1364-8535