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Table 1 Genetic variants nominally significantly associated with sepsis risk in meta-analyses

From: Host genetic variants in sepsis risk: a field synopsis and meta-analysis

Genes

Variant ID

Chr

Risk allele

Studies

Cases

Controls

Group

Genetic models

OR (95% CI)

P value

I2 (%)

Pheterogeneity

Level of evidence

Venice criteria

TLR1

rs5743551

4

G

4

1224

943

All/Adult

R

1.52(1.16–2.00)

0.002

0

0.54

Moderate

BAA

TLR1

rs5743551

4

G

4

1224

943

All/Adult

A

1.17(1.02–1.34)

0.02

0

0.42

Strong

AAA

TLR1

rs5743551

4

G

3

978

492

White

R

1.78(1.18–2.69)

0.006

0

0.59

Moderate

BAA

TLR1

rs5743551

4

G

3

978

492

White

A

1.24(1.04–1.47)

0.02

0

0.41

Weak

BAC

TLR2

rs5743708

4

A

10

948

1573

Adult

D

1.75(1.11–2.75)

0.02

30

0.19

Moderate

BBA

TLR2

rs5743708

4

A

7

720

695

Adult

A

2.04(1.20–3.48)

0.009

0

0.45

Moderate

BAA

TLR2

rs5743708

4

G

4

308

1087

Pediatric

D

0.43(0.20–0.89)

0.02

0

0.56

Moderate

BAA

TLR2

rs5743708

4

G

4

308

1087

Pediatric

A

0.43(0.21–0.90)

0.03

0

0.57

Strong

AAA

LBP

rs2232618

20

C

4

615

1267

All

D

1.93(1.49–2.48)

< 0.0001

0

0.41

Moderate

BAA

LBP

rs2232618

20

C

3

501

738

All/Adult

A

2.10(1.58–2.78)

< 0.0001

0

0.62

Moderate

BAA

RAGE

rs1800625

6

T

4

977

1339

All

D

0.59(0.48–0.73)

< 0.0001

0

0.69

Strong

AAA

RAGE

rs1800625

6

T

4

977

1339

All

R

0.47(0.24–0.96)

0.04

0

0.79

Strong

AAA

RAGE

rs1800625

6

T

4

977

1339

All

A

0.61(0.51–0.74)

< 0.0001

0

0.78

Strong

AAA

RAGE

rs1800624

6

T

3

662

838

All

A

0.78(0.63–0.97)

0.02

10

0.33

Strong

AAA

NOD2

rs2066844

16

T

3

229

943

All/White

D

2.25(1.39–3.64)

0.001

0

0.55

Moderate

BAA

NOD2

rs2066847

16

insC

5

326

1629

All/White

D

2.37(1.49–3.75)

0.0002

0

0.58

Moderate

BAA

MBL2

A/O haplotype

10

O

23

3549

5517

All/White

D

1.25(1.05–1.48)

0.01

63

< 0.001

Weak

ACC

MBL2

A/O haplotype

10

O

16

3353

4765

All/White

A

1.19(1.04–1.36)

0.01

57

0.002

Weak

ACC

MBL2

A/O haplotype

10

O

7

307

960

Pediatric

D

1.61(1.23–2.12)

0.0006

24

0.24

Moderate

BAB

MBL2

A/O haplotype

10

O

3

176

445

Pediatric

A

1.40(1.03–1.91)

0.03

0

0.72

Moderate

BAA

TNFA

rs1799724

6

T

3

502

1373

All/Adult

D

1.29(1.01–1.64)

0.04

0

0.761

Weak

BAC

TNFA

rs1800629

6

A

41

5540

9709

All

D

1.35(1.13–1.62)

0.001

71

< 0.001

Weak

ACC

TNFA

rs1800629

6

A

33

4859

8386

All

R

1.32(1.05–1.67)

0.02

16

0.23

Moderate

BAA

TNFA

rs1800629

6

A

33

4859

8386

All

A

1.21(1.04–1.42)

0.02

66

< 0.001

Weak

ACB

TNFA

rs1800629

6

A

12

1241

1715

Asian

D

2.16(1.75–2.67)

< 0.0001

37

0.09

Moderate

BBA

TNFA

rs1800629

6

A

11

1209

1645

Asian

R

2.56(1.44–4.57)

0.001

0

0.77

Weak

CAC

TNFA

rs1800629

6

A

11

1209

1645

Asian

A

1.99(1.64–2.42)

< 0.0001

30

0.16

Moderate

ABA

TNFA

rs1800629

6

A

30

4114

5983

Adult

D

1.51(1.20–1.90)

< 0.0001

74

< 0.001

Weak

ACC

TNFA

rs1800629

6

A

25

3515

4751

Adult

R

1.49(1.12–1.97)

0.005

17

0.24

Moderate

BAA

TNFA

rs1800629

6

A

25

3515

4751

Adult

A

1.30(1.06–1.61)

0.01

70

< 0.001

Weak

ACA

TNFA

rs361525

6

A

5

808

1457

All/Adult

R

4.88(2.19–10.87)

< 0.0001

0

0.85

Weak

CAA

TNFA

rs361525

6

A

4

745

903

Asian

D

2.05(1.06–3.96)

0.03

65

0.04

Weak

BCC

TNFA

rs361525

6

A

4

745

903

Asian

A

1.79(1.39–2.30)

< 0.0001

18

0.3

Moderate

BAA

LTA

rs909253

6

T

30

4662

7473

All

D

0.83(0.71–0.97)

0.02

64

< 0.001

Weak

ACA

LTA

rs909253

6

T

27

4512

6649

All

A

0.87(0.79–0.97)

0.01

58

< 0.001

Weak

ACA

LTA

rs909253

6

T

8

946

1355

Asian

R

0.78(0.63–0.96)

0.02

0

0.57

Weak

BAC

LTA

rs909253

6

T

6

846

1240

Asian

A

0.86(0.76–0.97)

0.02

24

0.25

Strong

AAA

LTA

rs909253

6

T

27

4012

6659

Adult

D

0.79(0.67–0.94)

0.007

65

< 0.001

Weak

ACA

LTA

rs909253

6

T

26

3962

5953

Adult

R

0.85(0.75–0.96)

0.008

4

0.41

Strong

AAA

LTA

rs909253

6

T

24

3862

5835

Adult

A

0.84(0.75–0.94)

0.002

55

0.001

Weak

ACA

IL1B

rs143634

2

C

7

1095

1168

All

R

0.53(0.34–0.82)

0.004

0

0.84

Moderate

AAB

IL1B

rs143634

2

C

5

969

1004

White

R

0.51(0.32–0.80)

0.003

0

0.82

Strong

AAA

IL1B

rs143634

2

C

5

879

744

Adult

R

0.54(0.33–0.90)

0.02

0

0.7

Strong

AAA

IL6

rs1800796

7

G

3

298

341

Asian

R

0.53(0.29–0.96)

0.04

0

0.99

Weak

BAC

IL6

rs1800796

7

G

3

478

364

Adult

D

0.55(0.42–0.74)

< 0.0001

63

0.07

Weak

BCA

IL6

rs1800795

7

C

17

1903

4573

All/White

A

1.17(1.01–1.35)

0.03

61

0.001

Weak

ACA

IL6

rs1800795

7

C

11

1452

2786

Adult

R

1.43(1.19–1.73)

< 0.0001

42

0.06

Weak

BBC

IL6

rs1800795

7

C

10

1405

2723

Adult

A

1.24(1.06–1.46)

0.008

53

0.02

Weak

ACA

IL8

rs4073

4

T

11

1314

1605

All/adult

D

0.71(0.60–0.84)

< 0.0001

43

0.06

Moderate

ABA

IL8

rs4073

4

T

10

1224

1515

All/adult

R

0.71(0.52–0.97)

0.03

47

0.05

Moderate

ABA

IL8

rs4073

4

T

10

1224

1515

All/adult

A

0.76(0.63–0.92)

0.004

60

0.008

Weak

ACA

IL8

rs4073

4

T

7

830

1074

White

D

0.68(0.56–0.84)

0.0002

45

0.09

Moderate

BBA

IL8

rs4073

4

T

7

830

1074

White

A

0.74(0.58–0.95)

0.02

66

0.007

Weak

ACA

IL10

rs1800871

1

T

6

686

764

Asian

R

1.35(1.03–1.76)

0.03

37

0.16

Moderate

BBA

IFNG

rs2430561

12

T

5

715

759

All/Adult

D

1.34(1.07–1.68)

0.01

46

0.11

Moderate

ABA

CXCL1

rs1429638

4

A

3

589

1108

All/Asian/Adult

R

0.68(0.56–0.83)

< 0.0001

0

0.84

Moderate

BAA

CXCL1

rs1429638

4

A

3

589

1108

All/Asian/Adult

A

0.75(0.64–0.88)

< 0.0001

0

0.86

Moderate

AAB

CXCL12

rs266087

10

A

3

542

1006

All/Asian/Adult

R

0.75(0.57–0.99)

0.04

58

0.09

Weak

ACA

CXCL12

rs2297630

10

A

3

589

1109

All/Asian/Adult

R

0.63(0.50–0.79)

< 0.0001

0

0.9

Moderate

BAB

CXCL12

rs2297630

10

A

3

589

1109

All/Asian/Adult

A

0.67(0.54–0.82)

< 0.0001

0

0.89

Moderate

BAA

MIF

rs755622

22

G

4

408

399

All

R

0.42(0.22–0.79)

0.007

52

0.1

Weak

BCC

FCGR2A

rs1801274

1

G

8

754

1307

All/White

R

1.65(1.08–2.53)

0.02

68

0.003

Weak

BCC

FCGR2A

rs1801274

1

G

8

754

1307

All/White

A

1.25(1.09–1.44)

0.001

44

0.09

Moderate

ABA

PAI-1

rs1799768

7

4G

11

1962

1340

All/White

R

1.50(1.09–2.06)

0.01

69

0.0004

Weak

BCC

PAI-1

rs1799768

7

4G

10

1277

1275

All/White

A

1.32(1.01–1.72)

0.04

80

< 0.0001

Weak

ACC

PAI-1

rs1799768

7

4G

4

563

603

Pediatric

A

1.37(1.02–1.85)

0.04

65

0.03

Weak

ACC

ACE

rs4646994

17

ins

9

1139

3107

All

R

0.79(0.67–0.92)

0.003

43

0.08

Moderate

ABA

ACE

rs4646994

17

ins

4

534

781

Adult

R

0.73(0.58–0.92)

0.008

0

0.44

Moderate

BAA

ACE

rs4646994

17

ins

4

534

781

Adult

A

0.81(0.69–0.94)

0.008

43

0.15

Moderate

ABA

LCE4A

rs4845320

1

C

3

320

240

All

D

2.75(1.36–5.57)

0.005

0

0.47

Weak

CAA

LCE4A

rs4845320

1

C

3

320

240

All

A

2.77(1.41–5.44)

0.003

12

0.32

Weak

CAA

TAGAP

rs3127214

6

T

3

317

239

All

D

1.84(1.07–3.17)

0.03

15

0.31

Weak

CAA

TAGAP

rs3127214

6

T

3

317

239

All

A

2.01(1.20–3.36)

0.008

21

0.28

Weak

CAA

VDR

rs2228570

12

T

4

240

244

All

D

2.94(1.85–4.71)

< 0.0001

0

0.85

Moderate

BAA

VDR

rs2228570

12

T

3

180

184

White

D

3.15(1.87–5.31)

< 0.0001

0

0.78

Moderate

BAA

VDR

rs2228570

12

T

3

180

184

White

R

2.96(1.18–4.92)

< 0.0001

31

0.24

Weak

CBA

VDR

rs2228570

12

T

3

200

204

Adult

D

2.95(1.85–4.71)

< 0.0001

0

0.69

Weak

BAC

MIR608

rs4919510

5

C

3

502

766

All/Asian/Adult

D

1.82(1.39–2.38)

< 0.0001

0

0.85

Moderate

BAA

MIR608

rs4919510

5

C

3

502

766

All/Asian/Adult

R

1.34(1.03–1.75)

0.03

0

0.79

Moderate

BAA

MIR608

rs4919510

5

C

3

502

766

All/Asian/Adult

A

1.39(1.19–1.63)

< 0.0001

0

0.81

Strong

AAA

  1. D dominant model, R recessive model, A allelic model; A/O haplotype: combination of Arg52Cys, Gly54Asp, and Gly57GLu