From: Host genetic variants in sepsis risk: a field synopsis and meta-analysis
Genes | Variant ID | Chr | Risk allele | Studies | Cases | Controls | Group | Genetic models | OR (95% CI) | P value | I2 (%) | Pheterogeneity | Level of evidence | Venice criteria |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TLR1 | rs5743551 | 4 | G | 4 | 1224 | 943 | All/Adult | R | 1.52(1.16–2.00) | 0.002 | 0 | 0.54 | Moderate | BAA |
TLR1 | rs5743551 | 4 | G | 4 | 1224 | 943 | All/Adult | A | 1.17(1.02–1.34) | 0.02 | 0 | 0.42 | Strong | AAA |
TLR1 | rs5743551 | 4 | G | 3 | 978 | 492 | White | R | 1.78(1.18–2.69) | 0.006 | 0 | 0.59 | Moderate | BAA |
TLR1 | rs5743551 | 4 | G | 3 | 978 | 492 | White | A | 1.24(1.04–1.47) | 0.02 | 0 | 0.41 | Weak | BAC |
TLR2 | rs5743708 | 4 | A | 10 | 948 | 1573 | Adult | D | 1.75(1.11–2.75) | 0.02 | 30 | 0.19 | Moderate | BBA |
TLR2 | rs5743708 | 4 | A | 7 | 720 | 695 | Adult | A | 2.04(1.20–3.48) | 0.009 | 0 | 0.45 | Moderate | BAA |
TLR2 | rs5743708 | 4 | G | 4 | 308 | 1087 | Pediatric | D | 0.43(0.20–0.89) | 0.02 | 0 | 0.56 | Moderate | BAA |
TLR2 | rs5743708 | 4 | G | 4 | 308 | 1087 | Pediatric | A | 0.43(0.21–0.90) | 0.03 | 0 | 0.57 | Strong | AAA |
LBP | rs2232618 | 20 | C | 4 | 615 | 1267 | All | D | 1.93(1.49–2.48) | < 0.0001 | 0 | 0.41 | Moderate | BAA |
LBP | rs2232618 | 20 | C | 3 | 501 | 738 | All/Adult | A | 2.10(1.58–2.78) | < 0.0001 | 0 | 0.62 | Moderate | BAA |
RAGE | rs1800625 | 6 | T | 4 | 977 | 1339 | All | D | 0.59(0.48–0.73) | < 0.0001 | 0 | 0.69 | Strong | AAA |
RAGE | rs1800625 | 6 | T | 4 | 977 | 1339 | All | R | 0.47(0.24–0.96) | 0.04 | 0 | 0.79 | Strong | AAA |
RAGE | rs1800625 | 6 | T | 4 | 977 | 1339 | All | A | 0.61(0.51–0.74) | < 0.0001 | 0 | 0.78 | Strong | AAA |
RAGE | rs1800624 | 6 | T | 3 | 662 | 838 | All | A | 0.78(0.63–0.97) | 0.02 | 10 | 0.33 | Strong | AAA |
NOD2 | rs2066844 | 16 | T | 3 | 229 | 943 | All/White | D | 2.25(1.39–3.64) | 0.001 | 0 | 0.55 | Moderate | BAA |
NOD2 | rs2066847 | 16 | insC | 5 | 326 | 1629 | All/White | D | 2.37(1.49–3.75) | 0.0002 | 0 | 0.58 | Moderate | BAA |
MBL2 | A/O haplotype | 10 | O | 23 | 3549 | 5517 | All/White | D | 1.25(1.05–1.48) | 0.01 | 63 | < 0.001 | Weak | ACC |
MBL2 | A/O haplotype | 10 | O | 16 | 3353 | 4765 | All/White | A | 1.19(1.04–1.36) | 0.01 | 57 | 0.002 | Weak | ACC |
MBL2 | A/O haplotype | 10 | O | 7 | 307 | 960 | Pediatric | D | 1.61(1.23–2.12) | 0.0006 | 24 | 0.24 | Moderate | BAB |
MBL2 | A/O haplotype | 10 | O | 3 | 176 | 445 | Pediatric | A | 1.40(1.03–1.91) | 0.03 | 0 | 0.72 | Moderate | BAA |
TNFA | rs1799724 | 6 | T | 3 | 502 | 1373 | All/Adult | D | 1.29(1.01–1.64) | 0.04 | 0 | 0.761 | Weak | BAC |
TNFA | rs1800629 | 6 | A | 41 | 5540 | 9709 | All | D | 1.35(1.13–1.62) | 0.001 | 71 | < 0.001 | Weak | ACC |
TNFA | rs1800629 | 6 | A | 33 | 4859 | 8386 | All | R | 1.32(1.05–1.67) | 0.02 | 16 | 0.23 | Moderate | BAA |
TNFA | rs1800629 | 6 | A | 33 | 4859 | 8386 | All | A | 1.21(1.04–1.42) | 0.02 | 66 | < 0.001 | Weak | ACB |
TNFA | rs1800629 | 6 | A | 12 | 1241 | 1715 | Asian | D | 2.16(1.75–2.67) | < 0.0001 | 37 | 0.09 | Moderate | BBA |
TNFA | rs1800629 | 6 | A | 11 | 1209 | 1645 | Asian | R | 2.56(1.44–4.57) | 0.001 | 0 | 0.77 | Weak | CAC |
TNFA | rs1800629 | 6 | A | 11 | 1209 | 1645 | Asian | A | 1.99(1.64–2.42) | < 0.0001 | 30 | 0.16 | Moderate | ABA |
TNFA | rs1800629 | 6 | A | 30 | 4114 | 5983 | Adult | D | 1.51(1.20–1.90) | < 0.0001 | 74 | < 0.001 | Weak | ACC |
TNFA | rs1800629 | 6 | A | 25 | 3515 | 4751 | Adult | R | 1.49(1.12–1.97) | 0.005 | 17 | 0.24 | Moderate | BAA |
TNFA | rs1800629 | 6 | A | 25 | 3515 | 4751 | Adult | A | 1.30(1.06–1.61) | 0.01 | 70 | < 0.001 | Weak | ACA |
TNFA | rs361525 | 6 | A | 5 | 808 | 1457 | All/Adult | R | 4.88(2.19–10.87) | < 0.0001 | 0 | 0.85 | Weak | CAA |
TNFA | rs361525 | 6 | A | 4 | 745 | 903 | Asian | D | 2.05(1.06–3.96) | 0.03 | 65 | 0.04 | Weak | BCC |
TNFA | rs361525 | 6 | A | 4 | 745 | 903 | Asian | A | 1.79(1.39–2.30) | < 0.0001 | 18 | 0.3 | Moderate | BAA |
LTA | rs909253 | 6 | T | 30 | 4662 | 7473 | All | D | 0.83(0.71–0.97) | 0.02 | 64 | < 0.001 | Weak | ACA |
LTA | rs909253 | 6 | T | 27 | 4512 | 6649 | All | A | 0.87(0.79–0.97) | 0.01 | 58 | < 0.001 | Weak | ACA |
LTA | rs909253 | 6 | T | 8 | 946 | 1355 | Asian | R | 0.78(0.63–0.96) | 0.02 | 0 | 0.57 | Weak | BAC |
LTA | rs909253 | 6 | T | 6 | 846 | 1240 | Asian | A | 0.86(0.76–0.97) | 0.02 | 24 | 0.25 | Strong | AAA |
LTA | rs909253 | 6 | T | 27 | 4012 | 6659 | Adult | D | 0.79(0.67–0.94) | 0.007 | 65 | < 0.001 | Weak | ACA |
LTA | rs909253 | 6 | T | 26 | 3962 | 5953 | Adult | R | 0.85(0.75–0.96) | 0.008 | 4 | 0.41 | Strong | AAA |
LTA | rs909253 | 6 | T | 24 | 3862 | 5835 | Adult | A | 0.84(0.75–0.94) | 0.002 | 55 | 0.001 | Weak | ACA |
IL1B | rs143634 | 2 | C | 7 | 1095 | 1168 | All | R | 0.53(0.34–0.82) | 0.004 | 0 | 0.84 | Moderate | AAB |
IL1B | rs143634 | 2 | C | 5 | 969 | 1004 | White | R | 0.51(0.32–0.80) | 0.003 | 0 | 0.82 | Strong | AAA |
IL1B | rs143634 | 2 | C | 5 | 879 | 744 | Adult | R | 0.54(0.33–0.90) | 0.02 | 0 | 0.7 | Strong | AAA |
IL6 | rs1800796 | 7 | G | 3 | 298 | 341 | Asian | R | 0.53(0.29–0.96) | 0.04 | 0 | 0.99 | Weak | BAC |
IL6 | rs1800796 | 7 | G | 3 | 478 | 364 | Adult | D | 0.55(0.42–0.74) | < 0.0001 | 63 | 0.07 | Weak | BCA |
IL6 | rs1800795 | 7 | C | 17 | 1903 | 4573 | All/White | A | 1.17(1.01–1.35) | 0.03 | 61 | 0.001 | Weak | ACA |
IL6 | rs1800795 | 7 | C | 11 | 1452 | 2786 | Adult | R | 1.43(1.19–1.73) | < 0.0001 | 42 | 0.06 | Weak | BBC |
IL6 | rs1800795 | 7 | C | 10 | 1405 | 2723 | Adult | A | 1.24(1.06–1.46) | 0.008 | 53 | 0.02 | Weak | ACA |
IL8 | rs4073 | 4 | T | 11 | 1314 | 1605 | All/adult | D | 0.71(0.60–0.84) | < 0.0001 | 43 | 0.06 | Moderate | ABA |
IL8 | rs4073 | 4 | T | 10 | 1224 | 1515 | All/adult | R | 0.71(0.52–0.97) | 0.03 | 47 | 0.05 | Moderate | ABA |
IL8 | rs4073 | 4 | T | 10 | 1224 | 1515 | All/adult | A | 0.76(0.63–0.92) | 0.004 | 60 | 0.008 | Weak | ACA |
IL8 | rs4073 | 4 | T | 7 | 830 | 1074 | White | D | 0.68(0.56–0.84) | 0.0002 | 45 | 0.09 | Moderate | BBA |
IL8 | rs4073 | 4 | T | 7 | 830 | 1074 | White | A | 0.74(0.58–0.95) | 0.02 | 66 | 0.007 | Weak | ACA |
IL10 | rs1800871 | 1 | T | 6 | 686 | 764 | Asian | R | 1.35(1.03–1.76) | 0.03 | 37 | 0.16 | Moderate | BBA |
IFNG | rs2430561 | 12 | T | 5 | 715 | 759 | All/Adult | D | 1.34(1.07–1.68) | 0.01 | 46 | 0.11 | Moderate | ABA |
CXCL1 | rs1429638 | 4 | A | 3 | 589 | 1108 | All/Asian/Adult | R | 0.68(0.56–0.83) | < 0.0001 | 0 | 0.84 | Moderate | BAA |
CXCL1 | rs1429638 | 4 | A | 3 | 589 | 1108 | All/Asian/Adult | A | 0.75(0.64–0.88) | < 0.0001 | 0 | 0.86 | Moderate | AAB |
CXCL12 | rs266087 | 10 | A | 3 | 542 | 1006 | All/Asian/Adult | R | 0.75(0.57–0.99) | 0.04 | 58 | 0.09 | Weak | ACA |
CXCL12 | rs2297630 | 10 | A | 3 | 589 | 1109 | All/Asian/Adult | R | 0.63(0.50–0.79) | < 0.0001 | 0 | 0.9 | Moderate | BAB |
CXCL12 | rs2297630 | 10 | A | 3 | 589 | 1109 | All/Asian/Adult | A | 0.67(0.54–0.82) | < 0.0001 | 0 | 0.89 | Moderate | BAA |
MIF | rs755622 | 22 | G | 4 | 408 | 399 | All | R | 0.42(0.22–0.79) | 0.007 | 52 | 0.1 | Weak | BCC |
FCGR2A | rs1801274 | 1 | G | 8 | 754 | 1307 | All/White | R | 1.65(1.08–2.53) | 0.02 | 68 | 0.003 | Weak | BCC |
FCGR2A | rs1801274 | 1 | G | 8 | 754 | 1307 | All/White | A | 1.25(1.09–1.44) | 0.001 | 44 | 0.09 | Moderate | ABA |
PAI-1 | rs1799768 | 7 | 4G | 11 | 1962 | 1340 | All/White | R | 1.50(1.09–2.06) | 0.01 | 69 | 0.0004 | Weak | BCC |
PAI-1 | rs1799768 | 7 | 4G | 10 | 1277 | 1275 | All/White | A | 1.32(1.01–1.72) | 0.04 | 80 | < 0.0001 | Weak | ACC |
PAI-1 | rs1799768 | 7 | 4G | 4 | 563 | 603 | Pediatric | A | 1.37(1.02–1.85) | 0.04 | 65 | 0.03 | Weak | ACC |
ACE | rs4646994 | 17 | ins | 9 | 1139 | 3107 | All | R | 0.79(0.67–0.92) | 0.003 | 43 | 0.08 | Moderate | ABA |
ACE | rs4646994 | 17 | ins | 4 | 534 | 781 | Adult | R | 0.73(0.58–0.92) | 0.008 | 0 | 0.44 | Moderate | BAA |
ACE | rs4646994 | 17 | ins | 4 | 534 | 781 | Adult | A | 0.81(0.69–0.94) | 0.008 | 43 | 0.15 | Moderate | ABA |
LCE4A | rs4845320 | 1 | C | 3 | 320 | 240 | All | D | 2.75(1.36–5.57) | 0.005 | 0 | 0.47 | Weak | CAA |
LCE4A | rs4845320 | 1 | C | 3 | 320 | 240 | All | A | 2.77(1.41–5.44) | 0.003 | 12 | 0.32 | Weak | CAA |
TAGAP | rs3127214 | 6 | T | 3 | 317 | 239 | All | D | 1.84(1.07–3.17) | 0.03 | 15 | 0.31 | Weak | CAA |
TAGAP | rs3127214 | 6 | T | 3 | 317 | 239 | All | A | 2.01(1.20–3.36) | 0.008 | 21 | 0.28 | Weak | CAA |
VDR | rs2228570 | 12 | T | 4 | 240 | 244 | All | D | 2.94(1.85–4.71) | < 0.0001 | 0 | 0.85 | Moderate | BAA |
VDR | rs2228570 | 12 | T | 3 | 180 | 184 | White | D | 3.15(1.87–5.31) | < 0.0001 | 0 | 0.78 | Moderate | BAA |
VDR | rs2228570 | 12 | T | 3 | 180 | 184 | White | R | 2.96(1.18–4.92) | < 0.0001 | 31 | 0.24 | Weak | CBA |
VDR | rs2228570 | 12 | T | 3 | 200 | 204 | Adult | D | 2.95(1.85–4.71) | < 0.0001 | 0 | 0.69 | Weak | BAC |
MIR608 | rs4919510 | 5 | C | 3 | 502 | 766 | All/Asian/Adult | D | 1.82(1.39–2.38) | < 0.0001 | 0 | 0.85 | Moderate | BAA |
MIR608 | rs4919510 | 5 | C | 3 | 502 | 766 | All/Asian/Adult | R | 1.34(1.03–1.75) | 0.03 | 0 | 0.79 | Moderate | BAA |
MIR608 | rs4919510 | 5 | C | 3 | 502 | 766 | All/Asian/Adult | A | 1.39(1.19–1.63) | < 0.0001 | 0 | 0.81 | Strong | AAA |