Table 3 Pre-ECMO parameters of patients supported with ECMO for respiratory failure
Variable | 2012 (nā=ā104) | 2013 (nā=ā100) | 2014 (nā=ā130) | 2015 (nā=ā153) | p value |
|---|---|---|---|---|---|
Vital signs | |||||
āMAP (mmHg) | 74 (62, 89) | 72 (59, 86) | 63 (56, 72) | 70 (57, 84) | 0.001 |
āHeart rate (/min) | 112 (98, 125) | 116 (101, 131) | 107 (94, 125) | 112 (94, 129) | 0.462 |
āRespiratory rate (/min) | 26 (20, 30) | 24 (20, 30) | 20 (16, 26) | 20 (16, 26) | <ā0.001 |
ECMO type | Ā | Ā | Ā | Ā | 0.003 |
āVeno-venous | 96 (92.3) | 95 (95.0) | 113 (86.9) | 125 (81.7) | Ā |
āVeno-arterial | 4 (3.8) | 2 (2.0) | 11 (8.5) | 25 (16.3) | Ā |
āVeno-arteriovenous | 3 (2.9) | 2 (2.0) | 6 (4.6) | 3 (2.0) | Ā |
āOther | 1 (1.0) | 1 (1.0) | 0 (0.0) | 0 (0.0) | Ā |
Arterial blood gases | |||||
āpH | 7.31 (7.17, 7.43) | 7.25 (7.17, 7.36) | 7.26 (7.15, 7.37) | 7.29 (7.18, 7.38) | 0.081 |
āPaO2 (mmHg) | 60 (52, 74) | 66 (56, 79) | 62 (50, 75) | 61 (46, 76) | 0.211 |
āPaCO2 (mmHg) | 52 (40, 62) | 56 (41, 72) | 51 (39, 71) | 47 (36, 59) | 0.013 |
āHCO3ā (mEq/L) | 24.3 (21.1, 31.0) | 24.1 (19.9, 29.5) | 22.4 (18.1, 27.9) | 22.0 (18.2, 25.5) | 0.003 |
āSaO2 (%) | 88 (83, 92) | 89 (85, 94) | 88 (79, 93) | 87 (75, 93) | 0.243 |
Ventilation parameters | |||||
āPaO2/FiO2 | 62 (53, 80) | 72 (59, 96) | 65 (53, 90) | 65 (48, 97) | 0.131 |
āFiO2 | 100 (100, 100) | 100 (90, 100) | 100 (80, 100) | 100 (80, 100) | 0.069 |
āPEEP (cmH2O) | 10 (6, 12) | 8 (5, 12) | 10 (6, 10) | 10 (7, 12) | 0.119 |
āPIP (cmH2O) | 28 (24, 33) | 30 (25, 34) | 28 (23, 33) | 28 (24, 31) | 0.382 |
āTidal volume (ml/kg) | 389 (298, 575) | 420 (321, 513) | 444 (340, 600) | 428 (299, 518) | 0.255 |
āDriving pressure (cmH2O) | 18 (14, 24) | 20 (16, 25) | 18 (15, 23) | 18 (15, 21) | 0.077 |
āMinute ventilation (L/min) | 10.9 (7.8, 14.6) | 9.6 (7.7, 12.7) | 9.5 (7.2, 12.2) | 9.3 (6.8, 12.0) | 0.035 |
Interval MVāECMO (days) | 2 (0, 7) | 1 (0, 5) | 1 (0, 5) | 2 (0, 5) | 0.090 |
ECMO duration (days) | 7 (4, 14) | 8 (5, 22) | 8 (3, 13) | 7 (4, 24) | 0.305 |
Hospital stay (days) | 32 (17, 47) | 34 (19, 65) | 39 (18, 73) | 34 (17, 60) | 0.318 |
Tracheostomy | 32 (30.8) | 38 (38.0) | 61 (48.8) | 68 (46.3) | 0.023 |
Weaning rate | 56 (53.8) | 50 (50.0) | 86 (66.2) | 86 (56.2) | 0.075 |
Survival rate | 32 (30.8) | 35 (35.0) | 67 (51.5) | 55 (35.9) | 0.005 |