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Table 3 Categorical variables and outcome/treatment variables not included in the mixture modeling

From: Identification of subclasses of sepsis that showed different clinical outcomes and responses to amount of fluid resuscitation: a latent profile analysis

Clinical variables, n (%) Profile 1 (n = 10,340) Profile 2 (n = 1305) Profile 3 (n = 1635) Profile 4 (n = 1713) P values
Male gender 5539 (53.6) 601 (46.1) 943 (57.7) 884 (51.6) <0.001
Ethnicity      <0.001
 Asian 246 (2.4) 19 (1.5) 45 (2.8) 64 (3.7)  
 Black 879 (8.5) 156 (12.0) 269 (16.5) 216 (12.6)  
 Hispanic 331 (3.2) 34 (2.6) 64 (3.9) 59 (3.4)  
 Unknown 1217 (11.8) 126 (9.7) 186 (11.4) 184 (10.7)  
 White 7667 (74.1) 970 (74.3) 1071 (65.5) 1190 (69.5)  
Admission type      <0.001
 Elective 648 (6.3) 43 (3.3) 51 (3.1) 84 (4.9)  
 Emergency 9438 (91.3) 1229 (94.2) 1546 (94.6) 1581 (92.3)  
 Urgent 254 (2.5) 33 (2.5) 38 (2.3) 48 (2.8)  
Type of ICU      <0.001
 CCU 1307 (12.6) 190 (14.6) 236 (14.4) 166 (9.7)  
 CSRU 894 (8.6) 42 (3.2) 54 (3.3) 125 (7.3)  
 MICU 5515 (53.3) 874 (67.0) 1071 (65.5) 972 (56.7)  
 SICU 1515 (14.7) 123 (9.4) 201 (12.3) 309 (18.0)  
 TSICU 1109 (10.7) 76 (5.8) 73 (4.5) 141 (8.2)  
D1 fluid input (median [IQR]) 5115.43 [2661.98, 8800.37] 2624.94 [1320.00, 4925.19] 6047.19 [3001.75, 11,219.73] 5683.17 [3165.68, 9129.45] <0.001
D2 fluid input (median [IQR]) 2139.66 [900.00, 3871.71] 1638.55 [720.00, 2949.81] 2019.12 [592.79, 4435.06] 2690.00 [1209.69, 4589.09] <0.001
Vasopressor, n (%) 2558 (24.7) 254 (19.5) 855 (52.3) 485 (28.3) <0.001
SOFA (median [IQR]) 4.00 [2.00, 6.00] 4.00 [3.00, 6.00] 9.00 [6.00, 12.00] 8.00 [5.00, 10.00] <0.001
90-day mortality, n (%) 2358 (22.8) 346 (26.5) 744 (45.5) 557 (32.5) <0.001
Hospital LOS (median [IQR]) 12.00 [7.00, 20.00] 10.00 [6.00, 17.00] 10.00 [5.00, 19.00] 11.00 [6.00, 20.00] <0.001
ICU LOS (median [IQR]) 4.00 [2.00, 9.00] 4.00 [2.00, 9.00] 4.00 [2.00, 9.00] 4.00 [2.00, 10.00] <0.001
Hospital mortality, n (%) 1744 (16.9) 238 (18.2) 743 (45.4) 470 (27.4) <0.001
Use of RRT, n (%) 395 (3.8) 52 (4.0) 458 (28.0) 84 (4.9) <0.001
  1. Abbreviations: BP blood pressure, CCU coronary artery unit, CSRU cardiac surgery recovery unit, GCS Glasgow Coma Scale, ICU intensive care unit, IQR interquartile range, LOS length of stay, MICU medical intensive care unit, RRT renal replacement therapy, SICU surgical intensive care unit, SOFA sequential organ failure assessment, TSICU trauma-neuro intensive care unit, UO urine output