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Table 2 Continuous variables included in the mixture modeling

From: Identification of subclasses of sepsis that showed different clinical outcomes and responses to amount of fluid resuscitation: a latent profile analysis

Clinical variables, mean (SD) or median (IQR)

Profile 1 (n = 10,340)

Profile 2 (n = 1305)

Profile 3 (n = 1635)

Profile 4 (n = 1713)

P values

Age, years

66.81 (16.47)

68.25 (15.00)

63.79 (16.23)

69.21 (16.64)

<0.001

Ph

7.39 (0.06)

7.35 (0.09)

7.29 (0.10)

7.37 (0.08)

<0.001

Bicarbonate, mmol/L

22.92 (3.75)

32.48 (4.73)

17.19 (4.17)

23.00 (4.66)

<0.001

Hematocrit, %

31.61 (5.27)

33.24 (5.89)

31.56 (5.85)

32.71 (5.60)

<0.001

Platelet, ×109/L

208.00 [140.50, 288.00]

233.50 [171.00, 310.50]

183.00 [109.25, 278.00]

208.00 [146.00, 287.50]

<0.001

aPTT, s

38.14 (18.10)

35.51 (17.29)

50.91 (25.18)

37.42 (17.73)

<0.001

INR

1.57 (0.88)

1.57 (0.98)

2.48 (2.36)

1.59 (0.99)

<0.001

Creatinine, mg/dL

1.44 (1.02)

1.36 (1.09)

4.32 (3.01)

1.64 (1.38)

<0.001

Urine output, L/24 h

1.54 [0.93, 2.42]

1.48 [0.94, 2.23]

0.50 [0.14, 1.14]

1.32 [0.73, 2.12]

<0.001

Minimum GCS score

15.00 [14.00, 15.00]

15.00 [14.00, 15.00]

15.00 [14.00, 15.00]

7.00 [4.00, 9.00]

<0.001

Bilirubin, mg/dL

0.60 [0.40, 1.15]

0.50 [0.30, 0.80]

0.90 [0.40, 2.88]

0.60 [0.40, 1.10]

<0.001

Mean BP, mm Hg

80.44 (16.47)

80.15 (16.85)

76.57 (18.84)

82.50 (19.39)

<0.001

Vasopressor ratea

0.08 (0.63)

0.07 (0.85)

0.77 (2.96)

0.15 (0.82)

<0.001

PaO2, mm Hg

136.25 (69.02)

108.53 (48.23)

124.77 (57.29)

144.90 (77.48)

<0.001

PaCO2, mm Hg

38.75 (6.79)

63.57 (12.71)

35.31 (9.30)

40.42 (10.15)

<0.001

Lactate, mmol/L

2.13 (1.20)

1.59 (0.85)

4.57 (3.50)

2.49 (1.73)

<0.001

Temperature, °C

36.90 (0.72)

36.77 (0.64)

36.48 (0.93)

36.85 (0.85)

<0.001

Glucose, mg/dL

144.77 (54.97)

143.63 (49.28)

173.07 (98.95)

156.27 (70.68)

<0.001

Anion gap, mEq/L

14.37 (2.77)

12.26 (2.76)

22.32 (4.33)

15.10 (3.65)

<0.001

Chloride, mmol/L

105.25 (5.96)

98.70 (5.68)

102.09 (7.10)

106.57 (7.85)

<0.001

WBC, ×109/L

12.92 (9.20)

11.62 (6.37)

16.25 (22.96)

13.95 (12.96)

<0.001

Sodium, mmol/L

138.25 (4.93)

139.20 (4.79)

136.38 (5.85)

140.34 (6.63)

<0.001

Potassium, mmol/L

4.15 (0.59)

4.37 (0.70)

4.81 (0.88)

4.24 (0.67)

<0.001

Heart rate, /min

90.35 (16.82)

89.02 (16.11)

91.84 (18.48)

91.44 (17.52)

<0.001

Respiratory rate, /min

20.66 (4.44)

21.00 (4.35)

21.26 (4.90)

21.13 (4.82)

<0.001

  1. aVasopressors included dopamine and norepinephrine. Since the dosings of these drugs were in different scale, they were centered at mean and scaled by standard deviation and combined, referring to as vasopressors. For patients without using vasopressor, the value was 0.
  2. Abbreviations: aPTT activated partial thrombin time, BP blood pressure, GCS Glasgow Coma Scale, INR international normalized ratio, IQR interquartile ratio, PaCO2 partial pressure of carbon dioxide, PaO2 arterial partial oxygen pressure, pH potential hydrogen, SD standard deviation, WBC white blood cell count
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Critical Care

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