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Table 2 Continuous variables included in the mixture modeling

From: Identification of subclasses of sepsis that showed different clinical outcomes and responses to amount of fluid resuscitation: a latent profile analysis

Clinical variables, mean (SD) or median (IQR) Profile 1 (n = 10,340) Profile 2 (n = 1305) Profile 3 (n = 1635) Profile 4 (n = 1713) P values
Age, years 66.81 (16.47) 68.25 (15.00) 63.79 (16.23) 69.21 (16.64) <0.001
Ph 7.39 (0.06) 7.35 (0.09) 7.29 (0.10) 7.37 (0.08) <0.001
Bicarbonate, mmol/L 22.92 (3.75) 32.48 (4.73) 17.19 (4.17) 23.00 (4.66) <0.001
Hematocrit, % 31.61 (5.27) 33.24 (5.89) 31.56 (5.85) 32.71 (5.60) <0.001
Platelet, ×109/L 208.00 [140.50, 288.00] 233.50 [171.00, 310.50] 183.00 [109.25, 278.00] 208.00 [146.00, 287.50] <0.001
aPTT, s 38.14 (18.10) 35.51 (17.29) 50.91 (25.18) 37.42 (17.73) <0.001
INR 1.57 (0.88) 1.57 (0.98) 2.48 (2.36) 1.59 (0.99) <0.001
Creatinine, mg/dL 1.44 (1.02) 1.36 (1.09) 4.32 (3.01) 1.64 (1.38) <0.001
Urine output, L/24 h 1.54 [0.93, 2.42] 1.48 [0.94, 2.23] 0.50 [0.14, 1.14] 1.32 [0.73, 2.12] <0.001
Minimum GCS score 15.00 [14.00, 15.00] 15.00 [14.00, 15.00] 15.00 [14.00, 15.00] 7.00 [4.00, 9.00] <0.001
Bilirubin, mg/dL 0.60 [0.40, 1.15] 0.50 [0.30, 0.80] 0.90 [0.40, 2.88] 0.60 [0.40, 1.10] <0.001
Mean BP, mm Hg 80.44 (16.47) 80.15 (16.85) 76.57 (18.84) 82.50 (19.39) <0.001
Vasopressor ratea 0.08 (0.63) 0.07 (0.85) 0.77 (2.96) 0.15 (0.82) <0.001
PaO2, mm Hg 136.25 (69.02) 108.53 (48.23) 124.77 (57.29) 144.90 (77.48) <0.001
PaCO2, mm Hg 38.75 (6.79) 63.57 (12.71) 35.31 (9.30) 40.42 (10.15) <0.001
Lactate, mmol/L 2.13 (1.20) 1.59 (0.85) 4.57 (3.50) 2.49 (1.73) <0.001
Temperature, °C 36.90 (0.72) 36.77 (0.64) 36.48 (0.93) 36.85 (0.85) <0.001
Glucose, mg/dL 144.77 (54.97) 143.63 (49.28) 173.07 (98.95) 156.27 (70.68) <0.001
Anion gap, mEq/L 14.37 (2.77) 12.26 (2.76) 22.32 (4.33) 15.10 (3.65) <0.001
Chloride, mmol/L 105.25 (5.96) 98.70 (5.68) 102.09 (7.10) 106.57 (7.85) <0.001
WBC, ×109/L 12.92 (9.20) 11.62 (6.37) 16.25 (22.96) 13.95 (12.96) <0.001
Sodium, mmol/L 138.25 (4.93) 139.20 (4.79) 136.38 (5.85) 140.34 (6.63) <0.001
Potassium, mmol/L 4.15 (0.59) 4.37 (0.70) 4.81 (0.88) 4.24 (0.67) <0.001
Heart rate, /min 90.35 (16.82) 89.02 (16.11) 91.84 (18.48) 91.44 (17.52) <0.001
Respiratory rate, /min 20.66 (4.44) 21.00 (4.35) 21.26 (4.90) 21.13 (4.82) <0.001
  1. aVasopressors included dopamine and norepinephrine. Since the dosings of these drugs were in different scale, they were centered at mean and scaled by standard deviation and combined, referring to as vasopressors. For patients without using vasopressor, the value was 0.
  2. Abbreviations: aPTT activated partial thrombin time, BP blood pressure, GCS Glasgow Coma Scale, INR international normalized ratio, IQR interquartile ratio, PaCO2 partial pressure of carbon dioxide, PaO2 arterial partial oxygen pressure, pH potential hydrogen, SD standard deviation, WBC white blood cell count