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Table 2 Typical pharmacokinetic parameters, unexplained interindividual variability and residual variability obtained from the pharmacometric analysis

From: Tigecycline in critically ill patients on continuous renal replacement therapy: a population pharmacokinetic study

Pharmacokinetic parameter

Estimate

RSE

95% CIa

Interindividual variability (%CV)

Clearance (L/h) = θ1 × \( {\left(\mathrm{bilirubin}/2.3\right)}^{\theta_2} \)

 θ1

18.3

11.0

13.2, 22.7

43.6

 θ2

−0.29

33.1

−0.68, −0.10

 

Central volume of distribution (V1) (L)

58.7

21.3

29.3, 101.6

110.9

Peripheral volume of distribution (V2) (L)

154

9.5

124.3, 196.8

–

Distribution clearance (Q) (L/h)

56.4

15.3

41.1, 76.6

41.8

Dialysis clearance CVVHD (L/h)

1.69

15.4

1.26, 2.27

43.5

Dialysis clearance CVVHDF (L/h)

2.71

8.9

2.31, 3.16

–

Residual variability

 σproportional, pre-filter plasma (%CV)

16.9

16.1

10.9, 21.7

–

 σproportional, effluent (%CV)

40.6

13.1

30.4, 50.2

–

  1. CV coefficient of variation, CVVHD continuous veno-venous hemodialysis, CVVHDF continuous veno-venous hemodiafiltration, RSE relative standard error (reported on standard deviation scale for variability parameters)
  2. a95% confidence interval (CI) determined from a nonparametric bootstrap analysis (n = 1000)
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Critical Care

ISSN: 1364-8535