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Table 3 Multivariable generalized mixed model analyses relating levels and trends of four host response biomarkers to cytomegalovirus reactivation

From: Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study

Marker Baseline level (t = −2) Effect reactivation on level P value Time trend per day P value Effect reactivation on time trend P value
Primary comparisona
 IL-6 5.50 (3.31–7.68) −0.58 (−1.27–0.10) 0.03 −0.23 (−0.38 – −0.08) c < 0.001 0.07 (−0.02–0.16) 0.06
 IP-10 7.23 (5.71–8.72) −0.31 (−0.80–0.18) 0.10 −0.03 (−0.09–0.03) 0.18 0.07 (−0.01–0.16) 0.03
 IL-10 2.44 (0.33–4.45) −0.02 (−0.78–0.74) 0.94 −0.09 (−0.17 – −0.03) 0.007 0.07 (−0.02–0.18) 0.10
 IL-1RA 6.12 (3.77–8.47) −0.17 (−0.93–0.59) 0.57 −0.08 (−0.16–0.00) 0.01 0.02 (−0.09–0.14) 0.62
Secondary comparisonb
 IL-6 4.83 (2.53–7.15) −0.34 (−1.02–0.34) 0.21 −0.15 (−0.27 – −0.02) c 0.003 0.01 (−0.07–0.08) 0.82
 IP-10 6.00 (4.54–7.44) 0.14 (−0.34–0.62) 0.45 0.02 (−0.04–0.07) 0.45 0.03 (−0.06–0.12) 0.36
 IL-10 1.22 (−0.60–3.08) 0.17 (−0.38–0.72) 0.43 −0.04 (−0.11–0.01) 0.06 0.02 (−0.07–0.12) 0.50
 IL-1RA 4.97 (2.31–7.64) 0.06 (−0.76–0.89) 0.85 0.00 (−0.08–0.09) 0.91 −0.07 (−0.19–0.05) 0.15
  1. Abbreviations: CMV cytomegalovirus, IL interleukin, IP-10 interferon-gamma induced protein-10, RA receptor antagonist
  2. Data are presented as coefficient of the model (99% confidence interval) derived from generalized mixed model analyses. Age and Sequential Organ Failure Assessment (SOFA) score at t = 0 (day of viremia onset) were included as confounders in each model because a range was used as matching criteria for these co-variables. Baseline levels were derived from intercept estimates, and the effect of reactivation on the time trend was assessed by an interaction term between time and CMV reactivation
  3. aIn the primary comparison, patients with CMV reactivation were compared with matched CMV seropositive patients without reactivation
  4. bIn the secondary comparison, patients with CMV reactivation were compared with matched CMV seronegative patients
  5. cFinal models for IL-6 included a polynomial time effect; the estimates for t2 were 0.01 (0.00–0.03) in the primary comparison and 0.01 (0.00–0.03) in the secondary comparison