|
Marker
|
Baseline level (t = −2)
|
Effect reactivation on level
|
P value
|
Time trend per day
|
P value
|
Effect reactivation on time trend
|
P value
|
|---|
|
Primary comparisona
|
|
IL-6
|
5.50 (3.31–7.68)
|
−0.58 (−1.27–0.10)
|
0.03
|
−0.23 (−0.38 – −0.08) c
|
< 0.001
|
0.07 (−0.02–0.16)
|
0.06
|
|
IP-10
|
7.23 (5.71–8.72)
|
−0.31 (−0.80–0.18)
|
0.10
|
−0.03 (−0.09–0.03)
|
0.18
|
0.07 (−0.01–0.16)
|
0.03
|
|
IL-10
|
2.44 (0.33–4.45)
|
−0.02 (−0.78–0.74)
|
0.94
|
−0.09 (−0.17 – −0.03)
|
0.007
|
0.07 (−0.02–0.18)
|
0.10
|
|
IL-1RA
|
6.12 (3.77–8.47)
|
−0.17 (−0.93–0.59)
|
0.57
|
−0.08 (−0.16–0.00)
|
0.01
|
0.02 (−0.09–0.14)
|
0.62
|
|
Secondary comparisonb
|
|
IL-6
|
4.83 (2.53–7.15)
|
−0.34 (−1.02–0.34)
|
0.21
|
−0.15 (−0.27 – −0.02) c
|
0.003
|
0.01 (−0.07–0.08)
|
0.82
|
|
IP-10
|
6.00 (4.54–7.44)
|
0.14 (−0.34–0.62)
|
0.45
|
0.02 (−0.04–0.07)
|
0.45
|
0.03 (−0.06–0.12)
|
0.36
|
|
IL-10
|
1.22 (−0.60–3.08)
|
0.17 (−0.38–0.72)
|
0.43
|
−0.04 (−0.11–0.01)
|
0.06
|
0.02 (−0.07–0.12)
|
0.50
|
|
IL-1RA
|
4.97 (2.31–7.64)
|
0.06 (−0.76–0.89)
|
0.85
|
0.00 (−0.08–0.09)
|
0.91
|
−0.07 (−0.19–0.05)
|
0.15
|
- Abbreviations: CMV cytomegalovirus, IL interleukin, IP-10 interferon-gamma induced protein-10, RA receptor antagonist
- Data are presented as coefficient of the model (99% confidence interval) derived from generalized mixed model analyses. Age and Sequential Organ Failure Assessment (SOFA) score at t = 0 (day of viremia onset) were included as confounders in each model because a range was used as matching criteria for these co-variables. Baseline levels were derived from intercept estimates, and the effect of reactivation on the time trend was assessed by an interaction term between time and CMV reactivation
- aIn the primary comparison, patients with CMV reactivation were compared with matched CMV seropositive patients without reactivation
- bIn the secondary comparison, patients with CMV reactivation were compared with matched CMV seronegative patients
- cFinal models for IL-6 included a polynomial time effect; the estimates for t2 were 0.01 (0.00–0.03) in the primary comparison and 0.01 (0.00–0.03) in the secondary comparison
