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Table 1 Characteristics of intensive care unit patients with sepsis by cytomegalovirus reactivation status

From: Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study

Variables

Primary comparisona

Secondary comparisonb

CMVs + (n = 37)

CMV+c (n = 37)

P value

CMVs− (n = 36)

CMV+c (n = 36)

P value

Demographics and comorbidities

 Age, years

69

(63–76)

69

(62–77)

MF

68

(60–72)

69

(63–77)

MF

 Sex, male

22

(60)

22

(60)

MF

23

(64)

23

(64)

MF

 COPD

10

(27)

5

(14)

0.25

6

(17)

6

(17)

1.00

 Congestive heart failure

4

(11)

2

(5)

0.67

1

(3)

1

(3)

1.00

 Diabetes mellitus

3

(8)

9

(24)

0.11

7

(19)

8

(22)

1.00

 Solid or hematologic malignancy

2

(5)

4

(11)

0.67

8

(22)

6

(17)

0.77

 Chronic renal insufficiency

3

(8)

8

(22)

0.19

5

(14)

9

(25)

0.37

 Charlson comorbidity index

0

(0–1)

0

(0–1)

0.29

0

(0–2)

0

(0–2)

0.81

Characteristics at ICU admission

 Hospital (A versus B)

25

(68)

25

(68)

MF

28

(78)

28

(78)

MF

 Prior ICU admission

10

(27)

4

(11)

0.14

11

(31)

3

(8)

0.03

 Surgical reason for admission

13

(35)

11

(30)

0.62

15

(42)

9

(25)

0.21

 APACHE IV score

85

(65–103)

88

(66–114)

0.43

85

(72–96)

83

(66–111)

0.67

 Septic shock

24

(65)

23

(62)

0.81

26

(72)

25

(69)

0.80

 ARDS

27

(73)

26

(70)

0.80

24

(67)

23

(64)

0.80

 Source of infection

    

0.03

    

0.88

  - Pulmonary

20

(54)

14

(38)

 

16

(44)

15

(42)

 

  - Abdominal

5

(14)

15

(41)

 

11

(31)

13

(36)

 

  - Other

12

(32)

8

(21)

 

9

(25)

8

(22)

 

Characteristics at t = 0d

 Length of ICU stay until t = 0 (days)

7

(6–11)

7

(6–11)

MF

9

(6–11)

9

(6–11)

MF

 SOFA score

7

(4–8)

7

(4–8)

MF

7

(5–10)

8

(6–10)

MF

 Corticosteroids in 4 previous dayse

15

(41)

15

(41)

MF

17

(47)

17

(47)

MF

  1. Abbreviations: APACHE Acute Physiology and Chronic Health Evaluation, ARDS acute respiratory distress syndrome, CMVs+ cytomegalovirus (CMV) seropositive without reactivation, CMV+ CMV reactivation, CMVs− CMV seronegative, COPD chronic obstructive pulmonary disease, ICU intensive care unit, MF used as matching factor, SOFA Sequential Organ Failure Assessment
  2. Data are presented as medians (Q1–Q3) or frequencies (column percentages)
  3. aIn the primary comparison, patients with CMV reactivation were compared with matched CMV seropositive patients without reactivation
  4. bIn the secondary comparison, patients with CMV reactivation were compared with matched CMV seronegative patients
  5. cTwenty-eight patients with CMV reactivation are included in both matched comparisons
  6. dt = 0 is the ICU day of CMV reactivation; this length of stay also determines t = 0 in the matched patient without reactivation
  7. eHigh-dose corticosteroid was defined as a daily dose of at least 250 mg hydrocortisone or equivalent
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Critical Care

ISSN: 1364-8535