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Table 1 Characteristics of intensive care unit patients with sepsis by cytomegalovirus reactivation status

From: Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study

Variables Primary comparisona Secondary comparisonb
CMVs + (n = 37) CMV+c (n = 37) P value CMVs− (n = 36) CMV+c (n = 36) P value
Demographics and comorbidities
 Age, years 69 (63–76) 69 (62–77) MF 68 (60–72) 69 (63–77) MF
 Sex, male 22 (60) 22 (60) MF 23 (64) 23 (64) MF
 COPD 10 (27) 5 (14) 0.25 6 (17) 6 (17) 1.00
 Congestive heart failure 4 (11) 2 (5) 0.67 1 (3) 1 (3) 1.00
 Diabetes mellitus 3 (8) 9 (24) 0.11 7 (19) 8 (22) 1.00
 Solid or hematologic malignancy 2 (5) 4 (11) 0.67 8 (22) 6 (17) 0.77
 Chronic renal insufficiency 3 (8) 8 (22) 0.19 5 (14) 9 (25) 0.37
 Charlson comorbidity index 0 (0–1) 0 (0–1) 0.29 0 (0–2) 0 (0–2) 0.81
Characteristics at ICU admission
 Hospital (A versus B) 25 (68) 25 (68) MF 28 (78) 28 (78) MF
 Prior ICU admission 10 (27) 4 (11) 0.14 11 (31) 3 (8) 0.03
 Surgical reason for admission 13 (35) 11 (30) 0.62 15 (42) 9 (25) 0.21
 APACHE IV score 85 (65–103) 88 (66–114) 0.43 85 (72–96) 83 (66–111) 0.67
 Septic shock 24 (65) 23 (62) 0.81 26 (72) 25 (69) 0.80
 ARDS 27 (73) 26 (70) 0.80 24 (67) 23 (64) 0.80
 Source of infection      0.03      0.88
  - Pulmonary 20 (54) 14 (38)   16 (44) 15 (42)  
  - Abdominal 5 (14) 15 (41)   11 (31) 13 (36)  
  - Other 12 (32) 8 (21)   9 (25) 8 (22)  
Characteristics at t = 0d
 Length of ICU stay until t = 0 (days) 7 (6–11) 7 (6–11) MF 9 (6–11) 9 (6–11) MF
 SOFA score 7 (4–8) 7 (4–8) MF 7 (5–10) 8 (6–10) MF
 Corticosteroids in 4 previous dayse 15 (41) 15 (41) MF 17 (47) 17 (47) MF
  1. Abbreviations: APACHE Acute Physiology and Chronic Health Evaluation, ARDS acute respiratory distress syndrome, CMVs+ cytomegalovirus (CMV) seropositive without reactivation, CMV+ CMV reactivation, CMVs− CMV seronegative, COPD chronic obstructive pulmonary disease, ICU intensive care unit, MF used as matching factor, SOFA Sequential Organ Failure Assessment
  2. Data are presented as medians (Q1–Q3) or frequencies (column percentages)
  3. aIn the primary comparison, patients with CMV reactivation were compared with matched CMV seropositive patients without reactivation
  4. bIn the secondary comparison, patients with CMV reactivation were compared with matched CMV seronegative patients
  5. cTwenty-eight patients with CMV reactivation are included in both matched comparisons
  6. dt = 0 is the ICU day of CMV reactivation; this length of stay also determines t = 0 in the matched patient without reactivation
  7. eHigh-dose corticosteroid was defined as a daily dose of at least 250 mg hydrocortisone or equivalent