Table 1 Patients characteristics according to the diagnosis of ID (i.e. hepcidin < 20 ng/l)
Non-ID (n = 732) (hepcidin ≥ 20 ng/l) | ID (n = 429) (hepcidin < 20 ng/l) | p | |
|---|---|---|---|
Age (years) | 61 (50 to 72) | 59 (47 to 72) | 0.25 |
Women | 240 (32.8) | 183 (42.7) | 0.00081 |
Charlson’s score | 3 (1 to 4) | 3 (1 to 4) | 0.32 |
Diabetes mellitus | 112 (15.3) | 89 (20.7) | 0.02 |
Chronic heart failure | 41 (5.6) | 34 (7.9) | 0.14 |
Hypertension | 268 (36.6) | 185 (43.1) | 0.029 |
Liver disease | 31 (4.2) | 44 (10.3) | < 0.001 |
Cancer | 98 (13.4) | 43 (10) | 0.094 |
ICU admission | |||
SAPS II | 46 (34.5 to 59) | 46 (34 to 59) | 0.87 |
SOFA | 6 (4 to 9) | 6 (4 to 9) | 0.71 |
Septic shock | 172 (23.5) | 78 (18.2) | 0.038 |
eGFR (ml/min) | 82 (40.4 to 106) | 87.9 (56.2 to 109) | 0.0044 |
Hb (g/dl) | 10.2 (9 to 11.6) | 9.9 (9.1 to 11.1) | 0.032 |
ICU stay | |||
ICU LOS (days) | 13 (7 to 22) | 12 (7 to 20) | 0.19 |
Renal support n (%) | 140 (19.1) | 64 (14.9) | 0.079 |
Catecholamine n (%) | 547 (74.7) | 294 (68.5) | 0.025 |
Transfusion n (%) | 343 (46.9) | 162 (37.8) | 0.0027 |
ICU discharge | |||
Hb (g/dl) | 10.1 (9 to 11.3) | 9.8 (8.9 to 10.8) | 0.011 |
CRP (mg/l) | 69.4 (32.2 to 117.3) | 33 (13.9 to 66.7) | < 0.001 |
Ferritin (μg/l) | 543.5 (339.8 to 932.2) | 240 (138 to 366) | < 0.001 |
sTfR (mg/l) | 1 (0.8 to 1.4) | 1.4 (1 to 1.9) | < 0.001 |
sTfR/log ferritin | 0.37 (0.28 to 0.51) | 0.57 (0.43 to 0.85) | < 0.001 |
IL-6 (ng/l) | 37.1 (19.6 to 70) | 19.8 (9.4 to 38.4) | < 0.001 |
Outcome at one year | |||
- global score | 56.9 (35.9 to 76.6) | 53.6 (34.3 to 73.7) | 0.21 |
- Mental QOL (MCS) | 58.8 (36.9 to 77.9) | 57.9 (35.9 to 77) | 0.44 |
- Physical QOL (PCS) | 54.7 (33.6 to 78.8) | 50 (31.2 to 72.7) | 0.11 |
One-year mortality | 123 (16.8) | 99 (23.1) | 0.011 |