Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study

Table 2 Association between bio-ADM and 28-day mortality

Variables	Chi-square	added chi-square	p Value (added value)	Std. HR bio-ADM	p Value
bio-ADM (univariate)	54.8			2.3 [1.9–2.9]	< 0.0001
Adjusted for SOFA at admission	85.1	10.2	0.0014	1.6 [1.2–2.1]	0.0014
Adjusted for APACHE II at admission	88.9	24.4	< 0.0001	1.9 [1.5–2.4]	< 0.0001
Adjusted for covariates	132.1	12.2	0.0005	1.6 [1.1–2.5]	0.0004
bio-ADM (time-dependent Cox)	80.6	25.8	< 0.0001	2.5 [2.1–3.1]	< 0.0001
Adjusted for SOFA at admission	89.3	11.5	0.0007	1.8 [1.4–2.2]	< 0.0001
Adjusted for APACHE II at admission	108.4	19.5	< 0.0001	2.1 [1.7–2.6]	< 0.0001
Adjusted for SOFA (t-d*)	101.0	7.9	0.0049	1.5 [1.1–2.0]	0.0048
Adjusted for lactate (t-d*)	138.0	35.7	< 0.0001	1.9 [1.5–2.3]	< 0.0001

APACHE Acute Physiology and Chronic Health Evaluation II, bio-ADM Bioactive adrenomedullin, SOFA Sequential Organ Failure Assessment
Results are from uni- (chi-square), multi- (added chi-square), and *time-dependent Cox regression analysis. *Time-dependent analysis includes measurements observed at baseline and day 2. n = 562 for covariates (i.e., age, gender, comorbidities [cardiac and noncardiac], diagnosis [sepsis, septic shock], lactate) model due to missing data for time-dependent lactate, and n = 509 for models including *time-dependent SOFA score

ISSN: 1364-8535