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Table 2 Association between bio-ADM and 28-day mortality

From: Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study

Variables Chi-square added chi-square p Value (added value) Std. HR bio-ADM p Value
bio-ADM (univariate) 54.8    2.3 [1.9–2.9] < 0.0001
 Adjusted for SOFA at admission 85.1 10.2 0.0014 1.6 [1.2–2.1] 0.0014
  Adjusted for APACHE II at admission 88.9 24.4 < 0.0001 1.9 [1.5–2.4] < 0.0001
  Adjusted for covariates 132.1 12.2 0.0005 1.6 [1.1–2.5] 0.0004
bio-ADM (time-dependent Cox) 80.6 25.8 < 0.0001 2.5 [2.1–3.1] < 0.0001
  Adjusted for SOFA at admission 89.3 11.5 0.0007 1.8 [1.4–2.2] < 0.0001
  Adjusted for APACHE II at admission 108.4 19.5 < 0.0001 2.1 [1.7–2.6] < 0.0001
  Adjusted for SOFA (t-d*) 101.0 7.9 0.0049 1.5 [1.1–2.0] 0.0048
  Adjusted for lactate (t-d*) 138.0 35.7 < 0.0001 1.9 [1.5–2.3] < 0.0001
  1. APACHE Acute Physiology and Chronic Health Evaluation II, bio-ADM Bioactive adrenomedullin, SOFA Sequential Organ Failure Assessment
  2. Results are from uni- (chi-square), multi- (added chi-square), and *time-dependent Cox regression analysis. *Time-dependent analysis includes measurements observed at baseline and day 2. n = 562 for covariates (i.e., age, gender, comorbidities [cardiac and noncardiac], diagnosis [sepsis, septic shock], lactate) model due to missing data for time-dependent lactate, and n = 509 for models including *time-dependent SOFA score