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Table 3 Gene Ontology analysis in non-responder patients

From: Identification of a transcriptome profile associated with improvement of organ function in septic shock patients after early supportive therapy

GO groups Group-adjusted P value Leading GO ID Leading GO term Leading GO genes
Group 00 1.83E-5 GO:0019221 Cytokine-mediated signaling pathway 69
Group 01 1.14E-4 GO:0006633 Fatty acid biosynthetic process 20
Group 02 4.52E-5 GO:0030100 Regulation of endocytosis 28
Group 03 1.32E-6 GO:0030168 Platelet activation 28
Group 04 1.08E-4 GO:0033032 Regulation of myeloid cell apoptotic process 9
Group 05 7.87E-6 GO:0002576 Platelet degranulation 23
Group 06 8.84E-6 GO:0010506 Regulation of autophagy 39
Group 07 7.56E-5 GO:0002218 Activation of innate immune response 34
Group 08 1.18E-5 GO:0071222 Cellular response to lipopolysaccharide 29
Group 09 4.65E-5 GO:0030334 Regulation of cell migration 69
Group10 5.26E-5 GO:0042981 Regulation of apoptotic process 122
Group11 1.29E-6 GO:0043281 Regulation of cysteine-type endopeptidase activity involved in apoptotic process 33
Group12 1.78E-5 GO:1904951 Positive regulation of establishment of protein localization 56
Group13 5.59E-25 GO:0045055 Regulated exocytosis 122
Group14 3.21E-10 GO:1902531 Regulation of intracellular signal transduction 152
  1. Gene Ontology (GO) analysis was performed on the most significant 1120 differentially expressed genes in non-responders between time point 1 (T1) and T2. Each line reports a significantly enriched GO group with its adjusted P value. The name of the most significant GO term in the GO group is reported together with the number of genes in the GO term