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Table 3 Gene Ontology analysis in non-responder patients

From: Identification of a transcriptome profile associated with improvement of organ function in septic shock patients after early supportive therapy

GO groups

Group-adjusted P value

Leading GO ID

Leading GO term

Leading GO genes

Group 00

1.83E-5

GO:0019221

Cytokine-mediated signaling pathway

69

Group 01

1.14E-4

GO:0006633

Fatty acid biosynthetic process

20

Group 02

4.52E-5

GO:0030100

Regulation of endocytosis

28

Group 03

1.32E-6

GO:0030168

Platelet activation

28

Group 04

1.08E-4

GO:0033032

Regulation of myeloid cell apoptotic process

9

Group 05

7.87E-6

GO:0002576

Platelet degranulation

23

Group 06

8.84E-6

GO:0010506

Regulation of autophagy

39

Group 07

7.56E-5

GO:0002218

Activation of innate immune response

34

Group 08

1.18E-5

GO:0071222

Cellular response to lipopolysaccharide

29

Group 09

4.65E-5

GO:0030334

Regulation of cell migration

69

Group10

5.26E-5

GO:0042981

Regulation of apoptotic process

122

Group11

1.29E-6

GO:0043281

Regulation of cysteine-type endopeptidase activity involved in apoptotic process

33

Group12

1.78E-5

GO:1904951

Positive regulation of establishment of protein localization

56

Group13

5.59E-25

GO:0045055

Regulated exocytosis

122

Group14

3.21E-10

GO:1902531

Regulation of intracellular signal transduction

152

  1. Gene Ontology (GO) analysis was performed on the most significant 1120 differentially expressed genes in non-responders between time point 1 (T1) and T2. Each line reports a significantly enriched GO group with its adjusted P value. The name of the most significant GO term in the GO group is reported together with the number of genes in the GO term