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Table 2 Gene Ontology analysis in responder patients

From: Identification of a transcriptome profile associated with improvement of organ function in septic shock patients after early supportive therapy

GO groups Group-adjusted P value Leading GO ID Leading GO term Leading GO genes
Group 00 6.37E-5 GO:0001820 Serotonin secretion 6
Group 01 3.99E-5 GO:0006650 Glycerophospholipid metabolic process 44
Group 02 4.59E-5 GO:0042981 Regulation of apoptotic process 124
Group 03 7.67E-5 GO:0043281 Regulation of cysteine-type endopeptidase activity involved in apoptotic process 29
Group 04 8.10E-5 GO:0002237 Response to molecule of bacterial origin 40
Group 05 5.76E-5 GO:0007169 Transmembrane receptor protein tyrosine kinase signaling pathway 70
Group 06 6.17E-5 GO:0038083 Peptidyl-tyrosine autophosphorylation 14
Group 07 6.05E-5 GO:0042089 Cytokine biosynthetic process 20
Group 08, Group13 1.12E-7, 1.25E-16 GO:0002696 Positive regulation of leukocyte activation 48
Group 09 8.82E-20 GO:0042119 Neutrophil activation 92
Group10 6.79E-5 GO:0050663 Cytokine secretion 30
Group11 3.85E-12 GO:0002253 Activation of immune response 81
Group12 1.44E-9 GO:0009967 Positive regulation of signal transduction 149
Group13 1.25E-16 GO:0030217 T-cell differentiation 43
  1. Gene Ontology (GO) analysis was performed on the most significant 1146 differentially expressed genes in responders between time point 1 (T1) and T2. Each line reports a significantly enriched GO group with its adjusted P value. The name of the most significant GO term in the GO group is reported together with the number of genes in the GO term