Table 1 Clinical variables
Responders (n = 17) | Non-responders (n = 14) | P value | |
|---|---|---|---|
Demographic parameters | |||
Age, years | 62.8 (18.4) | 68.6 (20.7) | 0.42 |
Sex, female | 5 (29%) | 5 (36%) | 0.71 |
Body mass index, kg/m2 | 27.0 (4.6) | 26.9 (6.4) | 0.98 |
Source of infection | |||
Abdominal | 5 (29%) | 5 (36%) | 0.22 |
Respiratory | 4 (24%) | 7 (50%) | |
Urinary tract | 6 (35%) | 1 (7%) | |
Other | 2 (12%) | 1 (7%) | |
Clinical parameters | |||
Length of stay in ICU, days | 6.2 (4.9) | 11.9 (6.3) | 0.01 |
Length of stay in hospital, days | 21.0 (18.6) | 28.7 (17.9) | 0.31 |
Death in ICU | 2 (12%) | 4 (29%) | 0.24 |
Death in hospital | 2 (12%) | 5 (36%) | 0.11 |
APACHE II | 23.1 (6.8) | 25.1 (7.2) | 0.42 |
SOFA T1 | 11.6 (3.0) | 12.4 (2.4) | 0.39 |
SOFA T2 | 6.1 (1.6) | 11.4 (2.6) | P <0.001 |
Temperature, °C, T1 | 37.2 (1.2) | 37.8 (1.2) | 0.17 |
Temperature, °C, T2 | 37.8 (0.8) | 37.2 (0.8) | 0.02 |
Lactate, mmol/L, T1 | 4.0 (1.8) | 5.3 (2.8) | 0.17 |
Lactate, mmol/L, T2 | 1.5 (0.8) | 2.1 (0.9) | 0.10 |
SvcO2, %, T1 | 75.0 (5.57) | 74.36 (7.72) | 0.82 |
SvcO2, %, T2 | 68.5 (6.84) | 69.33 (9.38) | 0.84 |
Heart rate, bpm, T1 | 105.8 (28.8) | 109.2 (17.7) | 0.69 |
Heart rate, bpm, T2 | 89.2 (23.2) | 95.4 (21.8) | 0.46 |
Mean arterial pressure, mm Hg, T1 | 60.1 (4.7) | 57.4 (7.3) | 0.24 |
Mean arterial pressure, mm Hg, T2 | 67.5 (9.9) | 66.0 (7.0) | 0.62 |
Hydrocortisone T1 | 0 (0%) | 0 (0%) | – |
Hydrocortisone T2 | 1 (6%) | 0 (0%) | 0.36 |
Vasopressor treatment T1 | 17 (100%) | 14 (100%) | 0.36 |
Vasopressor treatment T2 | 3 (18%) | 14 (100%) | P <0.001 |
Norepinehrine dose, μg/kg per min, T1 | 0.26 (0.19) | 0.49 (0.38) | 0.06 |
Norepinehrine dose, μg/kg per min, T2 | 0.09 (0.04) | 0.24 (0.33) | 0.12 |
Fluid balance, mL, T1 | 2229 (2468) | 3498 (1943) | 0.12 |
Fluid balance, mL, T2 | 135 (1203) | 1566 (2062) | 0.03 |
Urinary output, mL, T1 | 1674 (745) | 1194 (750) | 0.09 |
Urinary output, mL, T2 | 2273 (849) | 2040 (1691) | 0.65 |
Creatinine, mg/dL, T1 | 1.73 (1.17) | 1.65 (0.83) | 0.83 |
Creatinine, mg/dL, T2 | 1.20 (1.01) | 1.46 (0.95) | 0.46 |
Renal replacement therapy T1 | 1 (6%) | 0 (0%) | 0.36 |
Renal replacement therapy T2 | 0 (0%) | 0 (0%) | – |
Mechanical ventilation T1 | 13 (76%) | 13 (93%) | 0.22 |
Mechanical ventilation T2 | 9 (53%) | 11 (79%) | 0.14 |
paO2/FiO2, mm Hg, T1 | 203.9 (110.5) | 205.7 (147.4) | 0.97 |
paO2/FiO2, mm Hg, T2 | 271.0 (102.3) | 219.4 (48.6) | 0.08 |
Total leukocyte count, 103/mm3, T1 | 15.92 (15.37) | 15.35 (9.27) | 0.90 |
Total leukocyte count, 103/mm3, T2 | 14.08 (9.05) | 16.76 (8.53) | 0.42 |
Lymphocyte count, 103/mm3, T1 | 0.85 (0.53) | 1.00 (0.93) | 0.60 |
Lymphocyte count, 103/mm3, T2 | 0.90 (0.53) | 0.72 (0.45) | 0.34 |
C-reactive protein, mg/L, T1 | 245.2 (127.1) | 217.0 (156.0) | 0.59 |
C-reactive protein, mg/L, T2 | 224.2 (110.2) | 248.1 (127.1) | 0.59 |
Fibrinogen, mg/L, T1 | 5.34 (2.30) | 4.60 (1.10) | 0.27 |
Fibrinogen, mg/L, T2 | 5.98 (2.28) | 5.81 (2.06) | 0.85 |