TY - JOUR AU - Barcella, Matteo AU - Bollen Pinto, Bernardo AU - Braga, Daniele AU - D’Avila, Francesca AU - Tagliaferri, Federico AU - Cazalis, Marie-Angelique AU - Monneret, Guillaume AU - Herpain, Antoine AU - Bendjelid, Karim AU - Barlassina, Cristina PY - 2018 DA - 2018/11/21 TI - Identification of a transcriptome profile associated with improvement of organ function in septic shock patients after early supportive therapy JO - Critical Care SP - 312 VL - 22 IS - 1 AB - Septic shock is the most severe complication of sepsis and this syndrome is associated with high mortality. Treatment of septic shock remains largely supportive of hemodynamics and tissue perfusion. Early changes in organ function assessed by the Sequential Organ Function Assessment (SOFA) score are highly predictive of the outcome. However, the individual patient’s response to supportive therapy is very heterogeneous, and the mechanisms underlying this variable response remain elusive. The aim of the study was to investigate the transcriptome of whole blood in septic shock patients with different responses to early supportive hemodynamic therapy assessed by changes in SOFA scores within the first 48 h from intensive care unit (ICU) admission. SN - 1364-8535 UR - https://doi.org/10.1186/s13054-018-2242-3 DO - 10.1186/s13054-018-2242-3 ID - Barcella2018 ER -