Microcirculatory perfusion disturbances in septic shock: results from the ProCESS trial

Table 4 Differences in microcirculation parameters between survivors and nonsurvivors

Microcirculation parameter	Alive at discharge			Dead at discharge			Overall model Alive vs. dead
Microcirculation parameter	6 h n = 138	24 h n = 128	72 h n = 108	6 h n = 32	24 h n = 21	72 h n = 12	Beta	p Value*
TVD, mean ± SD	22.6 ± 4.2	23.0 ± 5.4	22.1 ± 4.0	21.1 ± 3.7	21.7 ± 5.7	19.3 ± 5.1	0.006	< 0.003
PVD, mean ± SD	21.1 ± 4.8	21.8 ± 5.7	21.0 ± 4.2	20.8 ± 4.9	19.3 ± 7.5	17.6 ± 4.8	0.005	< 0.04
De Backer score, mean ± SD	14.8 ± 2.6	15.1 ± 3.2	14.6 ± 2.5	14.5 ± 2.6	14.4 ± 2.3	12.5 ± 3.7	0.009	< 0.01
Heterogeneity index, median [IQR]	0.08 [0.00–0.43]	0.18 [0.00–0.46]	0.17 [0.00–0.49]	0.00 [0.00–0.51]	0.27 [0.00–0.67]	0.29 [0.00–0.60]	− 0.02	0.54
MFI, median [IQR]	2.92 [2.59–3.00]	2.85 [2.61–3.00]	2.88 [2.51–3.00]	2.96 [2.56–3.00]	2.67 [2.18–3.00]	2.71 [2.25–3.00]	0.05	0.33
PPV, median [IQR]	0.90 [0.83–0.97]	0.90 [0.85–0.96]	0.91 [0.83–0.95]	0.91 [0.82–0.95]	0.91 [0.83–0.95]	0.92 [0.69–1.00]	− 1.16	0.46

Abbreviations: MFI Microcirculatory flow index, PPV Proportion of perfused vessels, PVD Perfused vascular density, TVD Total vascular density
*In bold, p < 0.05 for pairwise comparisons at a given time point
The mean (± SD) and median [IQR] values are shown for each microcirculation parameter at 6-, 24-, and 72-h time points for survivors and nonsurvivors. TVD, PVD, and De Backer scores are lower in nonsurvivors, indicating an impaired microcirculation. In generalized estimating equation models, TVD, PVD, and De Backer scores were lower overall in nonsurvivors than in survivors

ISSN: 1364-8535