Microcirculatory perfusion disturbances in septic shock: results from the ProCESS trial

Table 3 Analysis of an association between arms and microcirculation parameters

	EGDT vs. control		Noninvasive vs. control
	Beta	p Value	Beta	p Value
Total vascular density (mm/mm²)	− 0.92	0.16	0.23	0.72
Perfused vascular density (mm/mm²)	− 1.29	0.07	− 0.24	0.74
De Backer score	− 0.42	0.30	0.05	0.91
Heterogeneity index	0.11	0.09	0.02	0.71
Microcirculatory flow index	− 0.06	< 0.02	− 0.02	0.36
Proportion perfused vessels (%)	− 0.05	0.09	0.00	0.94

EGDT Early goal-directed therapy
In this analysis, a generalized estimating equation model adjusted for age and Charlson comorbidity index score was used to assess differences in microcirculatory flow parameters between treatment arms. The only parameter found to be statistically significant was microcirculatory flow index, which was lower in the early goal-directed therapy group compared with control; however, the small difference limits the clinical significance of this finding. There was no significant difference across all other parameters when comparing each of the arms
Boldface indicates p<0.05

ISSN: 1364-8535