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Fig. 2 | Critical Care

Fig. 2

From: Mechanical ventilation enhances extrapulmonary sepsis-induced lung injury: role of WISP1–αvβ5 integrin pathway in TLR4-mediated inflammation and injury

Fig. 2

MTV enhances CLP-induced WISP1 and integrin β5 expression via TLR4-dependent pathway. WISP1 protein level (a) and integrin β5 expression (b) in lungs from each group of mice shown by western blot. MTV did not affect both levels and CLP led to small increases but two-hit model increased very significantly. Integrin β5 expression in lungs induced by CLP demonstrated in time-dependent fashion from wildtype mice (C57BL/6) but not TLR4 −/− mice (c). Corresponding actin identified for normalizing densitometry. *P < 0.05; **P < 0.01; ***P < 0.001. CLP cecal ligation and puncture, MTV moderate tidal ventilation, TLR4 toll-like receptor 4, WISP1 WNT1 inducible secreted protein

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