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Fig. 2 | Critical Care

Fig. 2

From: Early therapeutic plasma exchange in septic shock: a prospective open-label nonrandomized pilot study focusing on safety, hemodynamics, vascular barrier function, and biologic markers

Fig. 2

Hemodynamic improvements upon TPE. Box and whisker blots showing a the dose of norepinephrine (NE; μg/kg/min) immediately before the start of plasma exchange (pre) and after TPE (post) (p = 0.0002), and b the ratio of mean arterial pressure (MAP) over NE dose (p < 0.0001). c Peri-interventional (−60 to +105 min) longitudinal course of NE doses over the therapeutic plasma exchange (TPE) procedure assessed every 15 min (**p < 0.001, ***p < 0.0001, compared with time-point 0 highlighted in black). d Box and whisker blot of stroke volume variance (SVV) as a dynamic preload surrogate. Grey area highlights the reference range for healthy individuals (p = 0.008). e Box and whisker blot for fluid requirements 6 h before (pre) plasma exchange and 6 h after (post) TPE (p = 0.007)

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Critical Care

ISSN: 1364-8535