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Table 1 Ongoing and planned clinical trials of thiamine, ascorbic acid, and corticosteroids, in sepsis

From: Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation

Trial name Trial identifier Country Population Primary outcome
Ascorbic acid, Corticosteroids, and Thiamine in Sepsis (ACTS) Trial NCT03389555 USA Septic shock Change in SOFA score
Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) NCT03509350 USA Sepsis with acute cardiovascular or respiratory compromise Vasopressor- and ventilator-free days
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock (HYVCTTSSS) NCT03258684 China Sepsis or septic shock (Sepsis-3 Criteria) Hospital mortality
The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock NCT03335124 Slovenia Severe sepsis or septic shock Hospital mortality
Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis (ORANGES) NCT03422159 USA Sepsis or septic shock Hospital mortality
The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial (VITAMINS) NCT03333278 Australia and New Zealand Septic shock Vasopressor-free days
Evaluation of Hydrocortisone, Vitamin C and Thiamine for the Treatment of Septic Shock (HYVITS) NCT03380507 Qatar Septic shock Hospital mortality
Steroids, Thiamine, and Vitamin C in Septic Shock (STACSS) CTRI/2018/04/013384 India Septic shock Shock reversal
Thiamine, Vitamin C and Hydrocortisone in the Treatment of Septic Shock NCT03540628 USA Septic shock Mortality (as compared to the study by Marik et al. [6])