Fig. 1From: Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluationSuggested mechanisms for the efficacy of thiamine, ascorbic acid, and corticosteroids in sepsis. PDHÂ pyruvate dehydrogenase, ATPÂ adenosine triphosphate, NADPH nicotinamide adenine dinucleotide phosphate, PP2AÂ protein phosphatase 2, ROSÂ reactive oxygen species, BH4Â tetrahydrobiopterin, ICAMÂ intracellular adhesion molecule. A circled minus sign indicates an inhibitory action; arrows indicate an activating action; green-outlined boxes indicate a beneficial effect of the medication combination; red-outlined boxes indicate a potentially harmful effect attenuated by the medication combinationBack to article page