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Fig. 1 | Critical Care

Fig. 1

From: Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation

Fig. 1

Suggested mechanisms for the efficacy of thiamine, ascorbic acid, and corticosteroids in sepsis. PDH pyruvate dehydrogenase, ATP adenosine triphosphate, NADPH nicotinamide adenine dinucleotide phosphate, PP2A protein phosphatase 2, ROS reactive oxygen species, BH4 tetrahydrobiopterin, ICAM intracellular adhesion molecule. A circled minus sign indicates an inhibitory action; arrows indicate an activating action; green-outlined boxes indicate a beneficial effect of the medication combination; red-outlined boxes indicate a potentially harmful effect attenuated by the medication combination

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