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Fig. 3 | Critical Care

Fig. 3

From: Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice

Fig. 3

Microbiota depletion prior to mechanical ventilation worsened lung injury in high tidal volume (HTV)-ventilated mice. Mice received antibiotic broad-spectrum therapy (ATB). Control (Ctrl) mice did not receive antibiotic treatment. Ventilator-induced lung injury was induced 3 days after completing antibiotic treatment protocol by (HTV) ventilation (34 ml/kg; positive end-expiratory pressure = 2 cmH2O, 4 h). Additional groups of mice were ventilated with low tidal volume (LTV). Representative photographs of lungs after 4 h of ventilation with macroscopic lung lesions (reddish discolored areas (arrows)) are shown

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