Fig. 3
From: Angiotensin-(1–7) attenuates organ injury and mortality in rats with polymicrobial sepsis
Effects of angiotensin-(1–7) on changes in hemodynamic parameters in rats that underwent cecal ligation and puncture. Depicted are the changes in (a) mean arterial blood pressure and (b) heart rate during the experimental period. Rats underwent sham operation (SOP, n = 6), SOP plus angiotensin-(1–7) administration (1 mg/kg at 3 and 6 h after SOP procedure [SOP-Ad], n = 6), cecal ligation and puncture (CLP, n = 8), CLP plus angiotensin-(1–7) administration (1 mg/kg at 3 h after CLP procedure [CLP-As], n = 3), and CLP plus angiotensin-(1–7) administration (1 mg/kg at 3 and 6 h after CLP procedure [CLP-Ad], n = 8). Analysis of variance for repeated measures was used for analysis of time × group interaction. Data are shown as median and IQR. **p < 0.01, ***p < 0.001 CLP. vs. SOP; #p < 0.05 CLP-As or CLP-Ad vs. CLP