|
Agent
|
Shortage
|
Control
|
P value
|
|---|
|
Propofol
|
|
Used in x patients
|
132 (100)
|
139 (99)
|
0.507a
|
|
Cum. dosage, mg
|
3265 (1323–8869)
|
3353 (1230–7958)
|
0.535b
|
|
Avg. dosage, mg kg− 1 h− 1
|
1.94 (1.40–2.78)
|
2.22 (1.49–2.99)
|
0.084b
|
|
Dexmedetomidine
|
|
Used in x patients
|
25 (19)
|
18 (14)
|
0.218a
|
|
Cum. dosage, μg
|
4801 (1016–14,748)
|
4652 (1795–7378)
|
0.873b
|
|
Avg. dosage, μg kg−1 h− 1
|
0.68 (0.41–1.02)
|
0.90 (0.63–1.13)
|
0.076b
|
|
Clonidine
|
|
Used in x patients
|
16 (12)
|
17 (12)
|
0.866a
|
|
Cum. dosage, μg
|
8160 (4692–18,868)
|
7092 (3225–9606)
|
0.460b
|
|
Avg. dosage, μg h−1
|
85 (58–139)
|
90 (74–107)
|
0.857b
|
|
Ketamine
|
|
Used in x patients
|
19 (14)
|
12 (9)
|
0.180a
|
|
Cum. dosage, mg
|
5900 (940–11,800)
|
3367 (519–12,538)
|
0.626b
|
|
Avg. dosage, mg h−1
|
441 (124–1082)
|
299 (60–2203)
|
0.612b
|
|
Midazolam
|
|
Used in x patients
|
8 (6)
|
4 (3)
|
0.316a
|
|
Cum. dosage, mg
|
616 (271–1315)
|
2028 (645–3620)
|
0.089b
|
|
Avg. dosage, mg h−1
|
8 (4–11)
|
11 (8–17)
|
0.148b
|
- Data are given as absolute count with percentage or median with 25th and 75th percentile
- Statistical methods: aPearson’s chi-squared test with Yates’s continuity correction, bWilcoxon rank-sum test
- Cumulative dosages contain agents that were administered during intensive care unit admission and intraoperatively. Daily dosages are given per time or per body weight and time
