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Table 4 Dosages of sedatives

From: Impact of a remifentanil supply shortage on mechanical ventilation in a tertiary care hospital: a retrospective comparison

Agent Shortage Control P value
Propofol
 Used in x patients 132 (100) 139 (99) 0.507a
 Cum. dosage, mg 3265 (1323–8869) 3353 (1230–7958) 0.535b
 Avg. dosage, mg kg− 1 h− 1 1.94 (1.40–2.78) 2.22 (1.49–2.99) 0.084b
Dexmedetomidine
 Used in x patients 25 (19) 18 (14) 0.218a
 Cum. dosage, μg 4801 (1016–14,748) 4652 (1795–7378) 0.873b
 Avg. dosage, μg kg−1 h− 1 0.68 (0.41–1.02) 0.90 (0.63–1.13) 0.076b
Clonidine
 Used in x patients 16 (12) 17 (12) 0.866a
 Cum. dosage, μg 8160 (4692–18,868) 7092 (3225–9606) 0.460b
 Avg. dosage, μg h−1 85 (58–139) 90 (74–107) 0.857b
Ketamine
 Used in x patients 19 (14) 12 (9) 0.180a
 Cum. dosage, mg 5900 (940–11,800) 3367 (519–12,538) 0.626b
 Avg. dosage, mg h−1 441 (124–1082) 299 (60–2203) 0.612b
Midazolam
 Used in x patients 8 (6) 4 (3) 0.316a
 Cum. dosage, mg 616 (271–1315) 2028 (645–3620) 0.089b
 Avg. dosage, mg h−1 8 (4–11) 11 (8–17) 0.148b
  1. Data are given as absolute count with percentage or median with 25th and 75th percentile
  2. Statistical methods: aPearson’s chi-squared test with Yates’s continuity correction, bWilcoxon rank-sum test
  3. Cumulative dosages contain agents that were administered during intensive care unit admission and intraoperatively. Daily dosages are given per time or per body weight and time