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Table 3 Dosages of opioids

From: Impact of a remifentanil supply shortage on mechanical ventilation in a tertiary care hospital: a retrospective comparison

Agent Shortage Control P value
Remifentanil
 Used in x patients 36 (27) 129 (92) <0.001a
 Cum. dosage, mg 26.3 (8.8–90.3) 11.3 (4.5–29.1) 0.011b
 Avg. dosage, μg kg− 1 min− 1 0.10 (0.01–0.15) 0.10 (0.07–0.16) 0.975b
Fentanyl
 Used in x patients 89 (67) 55 (39) <0.001a
 Cum. dosage, μg 1400 (800–2040) 1130 (910–1400) 0.066b
 Avg. dosage, μg kg−1 h− 1 175 (111–232) 193 (150–150) 0.066b
Sufentanil
 Used in x patients 36 (27) 4 (3) <0.001a
 Cum. dosage, mg 3.9 (1.2–16.8) 16.9 (4.0–46.4) 0.443b
 Avg. dosage, μg kg−1 h− 1 1.21 (0.79–1.79) 1.44 (0.54–1.71) 0.892b
Morphine
 Used in x patients 22 (17) 1 (1) <0.001a
 Cum. dosage, mg 76 (31–361) 15 (15–15) 0.131b
 Avg. dosage, mg h−1 4.0 (2.4–5.1) 5.0 (5.0–5.0) 0.407b
Hydromorphone
 Used in x patients 4 (3) 0 (0) 0.115a
 Cum. dosage, mg 24 (9–28)
 Avg. dosage, mg h−1 0.28 (0.16–2.06)
Morphine equivalents pain management
 Cum. dosage, mg 23.6 (6.6–64.3) 27.1 (8.6–72.2) 0.350b
  1. Data are given as absolute count with percentage or median with 25th and 75th percentile
  2. Statistical methods: aPearson’s chi-squared test with Yates’s continuity correction, bWilcoxon rank-sum test
  3. Cumulative dosages contain agents that were administered during intensive care unit admission and intraoperatively. Daily dosages are given per time or per body weight and time. “Morphine equivalents pain management” contains the m. e. of every additional opioid for pain management (intravenous bolus, oral opioids, and transdermal applications).