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Table 3 Analysis of hypoglycaemia in reported studies

From: Systematic review of incretin therapy during peri-operative and intensive care

Author, year Threshold to define hypoglycaemia Incretin Comparator Weight Odds ratio
M-H, random, 95% CI
P value Odds ratio
M-H, random, 95% CI
n group n group
Besch, 2017 [19] 3.3 mmol L− 1 2 53 1 51 8.1% 1.96 [0.17, 22.32] 0.58
Brackbill, 2012 [20] 3.3 mmol L− 1 5 30 2 32 12.9% 3.00 [0.54, 16.81] 0.06
Deane, 2010 [22] 3.0 mmol L− 1 0 25 0 25   Not estimable 1
Galiatsatos, 2014 [24] 2.8 mmol L− 1 1 9 3 9 7.8% 0.25 [0.02, 3.04] 0.58
Garg, 2017 [35] 3.9 mmol L− 1 1 33 1 33 5.7% 1.00 [0.06, 16.69] 1
Holmberg, 2014 [25] 4.0 mmol L− 1 8 21 0 41 6.1% 52.26 [2.83, 966.6] 0.003
Kar, 2015 [26] Not stated 0 24 0 24   Not estimable 1
Kohl, 2014 [27] 3.8 mmol L− 1 0 37 0 40   Not estimable 1
Lipš, 2017 [17] 3.3 mmol L− 1 2 19 4 19 11.9% 0.44 [0.07, 2.76] 0.12
Meier, 2004 [29] 4.0 mmol L−1 0 8 0 8   Not estimable 1
Müssig, 2008 [31] Not stated 0 10 0 10   Not estimable 1
Pasquel, 2017 [33] 3.9 mmol L−1 13 138 17 139 24.7% 0.75 [0.35, 1.60] 0.45
Polderman, 2018 [18] 4.0 mmol L−1 1 44 5 106 9.5% 0.47 [0.05, 4.14] 0.26
Sokos, 2007 [34] 3.3 mmol L−1 1 10 2 10 7.4% 0.44 [0.03, 5.88] 0.39
Umpierrez, 2014 [33] 3.9 mmol L−1 3 56 2 26 11.8% 0.68 [0.11, 4.33] 0.86
Total (95% CI)    484   540 100% 0.97 [0.47, 2.02] 0.94
Total events   37   37     
  1. M-H Mantel-Haenszel
  2. Heterogeneity: Tau2 = 0.39, Chi2 = 12.94, df = 9 (P = 0.17); I2 = 30%
  3. Test for overall effect: Z = 0.08 (P = 0.94)