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Table 3 Analysis of hypoglycaemia in reported studies

From: Systematic review of incretin therapy during peri-operative and intensive care

Author, year

Threshold to define hypoglycaemia

Incretin

Comparator

Weight

Odds ratio

M-H, random, 95% CI

P value

Odds ratio

M-H, random, 95% CI

n

group

n

group

Besch, 2017 [19]

3.3 mmol L− 1

2

53

1

51

8.1%

1.96 [0.17, 22.32]

0.58

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Brackbill, 2012 [20]

3.3 mmol L− 1

5

30

2

32

12.9%

3.00 [0.54, 16.81]

0.06

Deane, 2010 [22]

3.0 mmol L− 1

0

25

0

25

 

Not estimable

1

Galiatsatos, 2014 [24]

2.8 mmol L− 1

1

9

3

9

7.8%

0.25 [0.02, 3.04]

0.58

Garg, 2017 [35]

3.9 mmol L− 1

1

33

1

33

5.7%

1.00 [0.06, 16.69]

1

Holmberg, 2014 [25]

4.0 mmol L− 1

8

21

0

41

6.1%

52.26 [2.83, 966.6]

0.003

Kar, 2015 [26]

Not stated

0

24

0

24

 

Not estimable

1

Kohl, 2014 [27]

3.8 mmol L− 1

0

37

0

40

 

Not estimable

1

Lipš, 2017 [17]

3.3 mmol L− 1

2

19

4

19

11.9%

0.44 [0.07, 2.76]

0.12

Meier, 2004 [29]

4.0 mmol L−1

0

8

0

8

 

Not estimable

1

Müssig, 2008 [31]

Not stated

0

10

0

10

 

Not estimable

1

Pasquel, 2017 [33]

3.9 mmol L−1

13

138

17

139

24.7%

0.75 [0.35, 1.60]

0.45

Polderman, 2018 [18]

4.0 mmol L−1

1

44

5

106

9.5%

0.47 [0.05, 4.14]

0.26

Sokos, 2007 [34]

3.3 mmol L−1

1

10

2

10

7.4%

0.44 [0.03, 5.88]

0.39

Umpierrez, 2014 [33]

3.9 mmol L−1

3

56

2

26

11.8%

0.68 [0.11, 4.33]

0.86

Total (95% CI)

  

484

 

540

100%

0.97 [0.47, 2.02]

0.94

Total events

 

37

 

37

    
  1. M-H Mantel-Haenszel
  2. Heterogeneity: Tau2 = 0.39, Chi2 = 12.94, df = 9 (P = 0.17); I2 = 30%
  3. Test for overall effect: Z = 0.08 (P = 0.94)