Table 1 Study characteristics
From: Systematic review of incretin therapy during peri-operative and intensive care
Author, year | Participants, setting, n | DM, n (%) | Intervention duration | Intervention, dose, n | Comparator, n | Standard glycaemic therapy | Outcome parameters |
|---|---|---|---|---|---|---|---|
Besch, 2017 [19] | CABG, OR + ICU n = 104 | 22 (21%) | 48 h | Exenatide IV 25 ng/min n = 53 | Standard glycaemic therapy n = 51 | Continuous insulin IV + bolus regimen | Glycaemia Insulin administration, complications, LoS |
Brackbill, 2012 [20] | CABG, ward, n = 62 | 62 (100%) | 4 d | Sitagliptin PO 100 mg q.d. n = 30 | Placebo n = 32 | Basal bolus insulin SC regimen | Glycaemia LoS |
Deane, 2009 [21] | Mechanically ventilated, ICU n = 7 | 0 (0%) | 240 min | GLP-1 IV 1.2 pmol/kg/min n = 7 | Placebo n = 7 | None | Glycaemia Insulinaemia, Glucagon, GLP-1 |
Deane, 2010 [22] | Mechanically ventilated, ICU n = 25 | 0 (0%) | 360 min | GLP-1 IV 1.2 pmol/kg/min n = 25 | Placebo n = 25 | None | Glycaemia Gastric emptying, glucose absorption, Insulinaemia, Glucagon |
Deane, 2011 [23] | Mechanically ventilated, ICU n = 11 | 11 (100%) | 240 min | GLP-1 IV 1.2 pmol/kg/min n = 11 | Placebo n = 11 | None | Glycaemia Insulinaemia, C-peptide, glucagon, FFA |
Galiatsatos, 2014 [24] | Surgical/burn, ICU n = 18 | 9 (50%) | 72 h | GLP-1 IV 1.5 pmol/kg/min n = 9 | Saline n = 9 | Intensive insulin treatment protocol | Glycaemia Insulin administration, glucagon, C-peptide, CV medication |
Garg, 2017 [35] | In hospital, ward (74% surgical) n = 66 | 66 (100%) | 5 d | Saxagliptin PO 5 mg q.d. n = 33 | Basal bolus insulin SC regimen n = 33 | Corrective insulin bolus regimen | Glycaemia Insulin administration, Treatment failure, LoS |
Holmberg, 2014 [25] | CABG, OR n = 62 | 12 (19%) | 390 min | Exenatide IV 43 ng/min n = 21 | RIPC n = 20 / Placebo n = 21 | Unknown | Cardiac enzymes Complications, LoS |
Kar, 2015 [26] | Mechanically ventilated, ICU n = 20 | 0 (0%) | 300 min | GIP IV 4 pmol/kg/min n = 20 | Placebo n = 20 | None | Glycaemia Gastric emptying, glucose absorption, insulinaemia |
Kohl, 2014 [27] | CABG, OR n = 77 | 11 (14%) | 72 h | GLP-1 IV 1.5 pmol/kg/min n = 37 | Placebo n = 40 | Continuous insulin IV + bolus regimen | Glycaemia Insulinaemia, glucagon, GLP-1, cortisol, FFA. |
Lee, 2013 [28] | Mechanically ventilated, ICU n = 20 | 0 (0%) | 300 min | GIP IV 4 pmol/kg/min n = 20 | Standard glycaemic therapy n = 20 | GLP-1 IV 1.2 pmol/kg/min (300 min) | Glycaemia Insulinaemia, glucagon, GLP-1, GIP, |
Lipš, 2017 [17] | CABG, OR n = 38 | 26 (68%) | 72 h | Exenatide IV 20 ng/min n = 19 | Placebo n = 19 | Intensive insulin treatment protocol | Glycaemia Echocardiography, CV medications, complications |
Meier, 2004 [29] | Major surgery, ward n = 8 | 100 (100%) | 8 h | GLP-1 IV 1.2 pmol/kg/min n = 8 | Placebo n = 8 | None | Glycaemia Insulinaemia, C-peptide, glucagon, GLP-1 |
Miller, 2017 [30] | Mechanically ventilated, ICU n = 12 | 0 (0%) | 270 min | GLP-1 IV 1.2 pmol/kg/min n = 12 | Placebo n = 12 | None | Glycaemia Glucose absorption |
Müssig, 2008 [31] | CABG, ICU n = 20 | 100 (100%) | 12 h | GLP-1 IV 3.6 pmol/kg/min n = 10 | Continuous insulin IV n = 10 | Corrective insulin bolus regimen | Glycaemia Insulin administration, haemodynamics |
Pasquel, 2017 [32] | In hospital, ward (16% surgical) n = 277 | 100 (100%) | 10 d | Sitagliptin PO 100 mg q.d. n = 138 | Bolus insulin regimen n = 139 | Basal (glargine) insulin regimen | Glycaemia Insulin administration, complications, treatment failure |
Polderman, 2018 [18] | Surgical, OR n = 150 | 100 (100%) | 2 d | Liraglutide SC 0.6 mg + 1.2 mg n = 44 | GIK infusion n = 53/Bolus insulin algorithm n = 53 | Bolus insulin treatment algorithm | Glycaemia Insulin administration, Potassium, nausea, complications |
Sokos, 2007 [34] | CABG, OR n = 20 | 5 (25%) | 60 h | GLP-1 IV 1.5 pmol/kg/min n = 10 | Standard insulin therapy n = 10 | Standard insulin therapy | Glycaemia LVEF, haemodynamics |
Umpierrez, 2014 [33] | In hospital, ward (45% surgical) n = 90 | 100 (100%) | 10 d | Sitagliptin PO 100 mg q.d. n = 27 / Sitagliptin + basal insulin n = 29 | Basal bolus insulin regimen n = 26 | Correction bolus insulin regimen | Glycaemia Insulin administration, complications, treatment failure |