| uCysC(−)/ AKI(−) | uCysC(+)/ AKI(−) | uCysC(−)/ AKI(+) | uCysC(+)/ AKI(+) | P value |
---|
Number | 301 (59.0) | 130 (25.5) | 43 (8.4) | 36 (7.1) | N/A |
Body weight, kg | 5.5 [3.0–12.0] | 2.4 [1.5–5.0]* | 10.0 [3.4–19.0]*# | 5.0 [1.4–13.0]# | <0.001 |
Male, n | 184 (61.1) | 68 (52.3) | 28 (65.1) | 24 (66.7) | 0.216 |
Illness severitya, score | 5 [2–7] | 8 [5–10]* | 7 [5–11]* | 12 [8–16.5]*#& | <0.001 |
MV, n | 77 (25.6) | 42 (32.3) | 19 (44.2)* | 24 (66.7)*# | <0.001 |
MV duration, days | 0 [0–0.38] | 0 [0–1.10] | 0 [0–3.96]* | 3.16 [0–5.65]*#& | <0.001 |
Severe AKIb, n | 0 (0) | 0 (0) | 14 (32.6)*# | 22 (61.1)*#& | <0.001 |
ICU LOS, hours | 121.0 [56.0–228.1] | 336.0 [132.9–774.0]* | 144.0 [63.0–288.0]# | 236.0 [137.0–917.8]*& | <0.001 |
Death, n | 6 (2.0) | 26 (20.0)* | 4 (9.3)* | 12 (33.3)*& | <0.001c |
- Values are median [interquartile range] or number (percentage). uCysC(−) indicates the absence of tubular injury, and uCysC(+) indicates the presence of tubular injury defined by the optimal cutoff value of the peak uCysC for predicting mortality (1260 ng/mg uCr)
- AKI acute kidney injury, ICU, intensive care unit, LOS length of stay, MV mechanical ventilation, uCysC urinary cystatin C, uCr urinary creatinine
- aIllness severity was assessed by the score for neonatal acute physiology in critically ill neonates and the pediatric risk of mortality III score in critically ill children
- bSevere AKI was defined as Kidney Disease: Improving Global Outcomes (KDIGO) stages 2 and 3
- cP = 0.001, after adjustment for body weight, illness severity, MV, and severe AKI
- *P < 0.05 vs. uCysC(−)/AKI(−). #P < 0.05 vs. uCysC(+)/AKI(−). &P < 0.05 vs. uCysC(−)/AKI(+)