| |
uCysC(−)/ AKI(−)
|
uCysC(+)/ AKI(−)
|
uCysC(−)/ AKI(+)
|
uCysC(+)/ AKI(+)
|
P value
|
|---|
|
Number
|
301 (59.0)
|
130 (25.5)
|
43 (8.4)
|
36 (7.1)
|
N/A
|
|
Body weight, kg
|
5.5 [3.0–12.0]
|
2.4 [1.5–5.0]*
|
10.0 [3.4–19.0]*#
|
5.0 [1.4–13.0]#
|
<0.001
|
|
Male, n
|
184 (61.1)
|
68 (52.3)
|
28 (65.1)
|
24 (66.7)
|
0.216
|
|
Illness severitya, score
|
5 [2–7]
|
8 [5–10]*
|
7 [5–11]*
|
12 [8–16.5]*#&
|
<0.001
|
|
MV, n
|
77 (25.6)
|
42 (32.3)
|
19 (44.2)*
|
24 (66.7)*#
|
<0.001
|
|
MV duration, days
|
0 [0–0.38]
|
0 [0–1.10]
|
0 [0–3.96]*
|
3.16 [0–5.65]*#&
|
<0.001
|
|
Severe AKIb, n
|
0 (0)
|
0 (0)
|
14 (32.6)*#
|
22 (61.1)*#&
|
<0.001
|
|
ICU LOS, hours
|
121.0 [56.0–228.1]
|
336.0 [132.9–774.0]*
|
144.0 [63.0–288.0]#
|
236.0 [137.0–917.8]*&
|
<0.001
|
|
Death, n
|
6 (2.0)
|
26 (20.0)*
|
4 (9.3)*
|
12 (33.3)*&
|
<0.001c
|
- Values are median [interquartile range] or number (percentage). uCysC(−) indicates the absence of tubular injury, and uCysC(+) indicates the presence of tubular injury defined by the optimal cutoff value of the peak uCysC for predicting mortality (1260 ng/mg uCr)
- AKI acute kidney injury, ICU, intensive care unit, LOS length of stay, MV mechanical ventilation, uCysC urinary cystatin C, uCr urinary creatinine
- aIllness severity was assessed by the score for neonatal acute physiology in critically ill neonates and the pediatric risk of mortality III score in critically ill children
- bSevere AKI was defined as Kidney Disease: Improving Global Outcomes (KDIGO) stages 2 and 3
- cP = 0.001, after adjustment for body weight, illness severity, MV, and severe AKI
- *P < 0.05 vs. uCysC(−)/AKI(−). #P < 0.05 vs. uCysC(+)/AKI(−). &P < 0.05 vs. uCysC(−)/AKI(+)
