| AUC | 95% CI | P value | Optimal cutoff value | Sensitivity | Specificity | LR+ | LR- |
---|
Illness severitya, score | 0.74 | 0.68–0.81 | <0.001 | 9.5 | 56.3% | 79.2% | 2.7 | 0.55 |
MVb | 0.73 | 0.65–0.80 | <0.001 | N/A | | | | |
AKI stagec | 0.60 | 0.50–0.69 | 0.020 | N/A | | | | |
Sepsisb | 0.59 | 0.50–0.69 | 0.033 | N/A | | | | |
Initial uCysC, ng/mg uCr | 0.76 | 0.69–0.83 | <0.001 | 471.5 | 83.3% | 60.2% | 2.1 | 0.28 |
Peak uCysC, ng/mg uCr | 0.81 | 0.75–0.88 | <0.001 | 1260.0 | 79.2% | 72.3% | 2.9 | 0.29 |
- AKI acute kidney injury, AUC the area under the ROC curve, CI confidence interval, ICU intensive care unit, LR+ likelihood ratio positive, LR- likelihood ratio negative, MV mechanical ventilation, N/A not applicable, uCysC urinary cystatin C, uCr urinary creatinine
- aIllness severity was assessed by the score for neonatal acute physiology in critically ill neonates and the pediatric risk of mortality III score in critically ill children
- bAdministered or developed during ICU stay
- cDeveloped during the first week after ICU admission