| |
AUC
|
95% CI
|
P value
|
Optimal cutoff value
|
Sensitivity
|
Specificity
|
LR+
|
LR-
|
|---|
|
Illness severitya, score
|
0.74
|
0.68–0.81
|
<0.001
|
9.5
|
56.3%
|
79.2%
|
2.7
|
0.55
|
|
MVb
|
0.73
|
0.65–0.80
|
<0.001
|
N/A
| | | | |
|
AKI stagec
|
0.60
|
0.50–0.69
|
0.020
|
N/A
| | | | |
|
Sepsisb
|
0.59
|
0.50–0.69
|
0.033
|
N/A
| | | | |
|
Initial uCysC, ng/mg uCr
|
0.76
|
0.69–0.83
|
<0.001
|
471.5
|
83.3%
|
60.2%
|
2.1
|
0.28
|
|
Peak uCysC, ng/mg uCr
|
0.81
|
0.75–0.88
|
<0.001
|
1260.0
|
79.2%
|
72.3%
|
2.9
|
0.29
|
- AKI acute kidney injury, AUC the area under the ROC curve, CI confidence interval, ICU intensive care unit, LR+ likelihood ratio positive, LR- likelihood ratio negative, MV mechanical ventilation, N/A not applicable, uCysC urinary cystatin C, uCr urinary creatinine
- aIllness severity was assessed by the score for neonatal acute physiology in critically ill neonates and the pediatric risk of mortality III score in critically ill children
- bAdministered or developed during ICU stay
- cDeveloped during the first week after ICU admission
