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Table 7 Performance of urinary cystatin C and clinical variables for prediction of ICU mortality (n = 510)

From: Subclinical acute kidney injury is associated with adverse outcomes in critically ill neonates and children

  AUC 95% CI P value Optimal cutoff value Sensitivity Specificity LR+ LR-
Illness severitya, score 0.74 0.68–0.81 <0.001 9.5 56.3% 79.2% 2.7 0.55
MVb 0.73 0.65–0.80 <0.001 N/A     
AKI stagec 0.60 0.50–0.69 0.020 N/A     
Sepsisb 0.59 0.50–0.69 0.033 N/A     
Initial uCysC, ng/mg uCr 0.76 0.69–0.83 <0.001 471.5 83.3% 60.2% 2.1 0.28
Peak uCysC, ng/mg uCr 0.81 0.75–0.88 <0.001 1260.0 79.2% 72.3% 2.9 0.29
  1. AKI acute kidney injury, AUC the area under the ROC curve, CI confidence interval, ICU intensive care unit, LR+ likelihood ratio positive, LR- likelihood ratio negative, MV mechanical ventilation, N/A not applicable, uCysC urinary cystatin C, uCr urinary creatinine
  2. aIllness severity was assessed by the score for neonatal acute physiology in critically ill neonates and the pediatric risk of mortality III score in critically ill children
  3. bAdministered or developed during ICU stay
  4. cDeveloped during the first week after ICU admission