| |
OR
|
95% CI
|
P value
|
AOR
|
95% CI
|
P value
|
|---|
|
Body weight, kg
|
1.00
|
0.97–1.03
|
0.968
|
0.99e
|
0.95–1.02
|
0.454
|
|
Illness severitya, score
|
1.14
|
1.09–1.19
|
<0.001
|
1.14f
|
1.09–1.20
|
<0.001
|
|
MVb
|
7.10
|
3.64–13.86
|
<0.001
|
4.72g
|
2.28–9.76
|
<0.001
|
|
MV duration, days
|
1.09
|
1.05–1.12
|
<0.001
|
1.07g
|
1.04–1.11
|
<0.001
|
|
AKIc
|
3.17
|
1.64–6.10
|
0.001
|
2.09g
|
0.94–-3.97
|
0.049
|
|
AKI stage
|
1.87
|
1.34–2.60
|
<0.001
|
1.49g
|
1.00–4.33
|
0.031
|
|
Severe AKIc
|
3.72
|
1.63–8.46
|
0.002
|
2.25g
|
0.91–5.57
|
0.079
|
|
Sepsisb
|
3.17
|
1.62–6.18
|
0.001
|
2.58h
|
1.22–5.45
|
0.013
|
|
Shock/DICb
|
2.44
|
1.22–4.87
|
0.011
|
1.32h
|
0.59–2.96
|
0.500
|
|
MODSb
|
2.52
|
1.28–4.94
|
0.007
|
1.18h
|
0.51–2.72
|
0.706
|
|
Furosemideb
|
2.67
|
1.46–4.87
|
0.001
|
1.09h
|
0.53–2.23
|
0.814
|
|
Initial uCysC, ng/mg uCr
|
1.19d
|
1.08–1.33
|
0.001
|
1.13d, h
|
1.01–1.26
|
0.041
|
|
Peak uCysC, ng/mg uCr
|
1.26d
|
1.16–1.38
|
<0.001
|
1.17d, h
|
1.07–1.28
|
<0.001
|
- AKI acute kidney injury, AOR adjusted OR, CI confidence interval, ICU intensive care unit, DIC disseminated intravascular coagulation, MODS, multi-organ dysfunction syndrome, MV mechanical ventilation, OR odds ratio, uCysC urinary cystatin C, uCr urinary creatinine
- aIllness severity was assessed by the score for neonatal acute physiology in critically ill neonates and the pediatric risk of mortality III score in critically ill children
- bAdministered or developed during ICU stay
- cDeveloped during the first week after ICU admission. Severe AKI was defined as Kidney Disease: Improving Global Outcomes (KDIGO) stages 2 and 3
- dOdds ratio represents the increase in risk per 10,000 ng/mg increase in uCysC/uCr
- eAfter adjustment for illness severity
- fAfter adjustment for body weight
- gAfter adjustment for body weight and illness severity
- hAfter adjustment for body weight, illness severity, MV, and AKI stage
