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Table 6 Association between urinary cystatin C or clinical variables and ICU mortality (n = 510)

From: Subclinical acute kidney injury is associated with adverse outcomes in critically ill neonates and children

  OR 95% CI P value AOR 95% CI P value
Body weight, kg 1.00 0.97–1.03 0.968 0.99e 0.95–1.02 0.454
Illness severitya, score 1.14 1.09–1.19 <0.001 1.14f 1.09–1.20 <0.001
MVb 7.10 3.64–13.86 <0.001 4.72g 2.28–9.76 <0.001
MV duration, days 1.09 1.05–1.12 <0.001 1.07g 1.04–1.11 <0.001
AKIc 3.17 1.64–6.10 0.001 2.09g 0.94–-3.97 0.049
AKI stage 1.87 1.34–2.60 <0.001 1.49g 1.00–4.33 0.031
Severe AKIc 3.72 1.63–8.46 0.002 2.25g 0.91–5.57 0.079
Sepsisb 3.17 1.62–6.18 0.001 2.58h 1.22–5.45 0.013
Shock/DICb 2.44 1.22–4.87 0.011 1.32h 0.59–2.96 0.500
MODSb 2.52 1.28–4.94 0.007 1.18h 0.51–2.72 0.706
Furosemideb 2.67 1.46–4.87 0.001 1.09h 0.53–2.23 0.814
Initial uCysC, ng/mg uCr 1.19d 1.08–1.33 0.001 1.13d, h 1.01–1.26 0.041
Peak uCysC, ng/mg uCr 1.26d 1.16–1.38 <0.001 1.17d, h 1.07–1.28 <0.001
  1. AKI acute kidney injury, AOR adjusted OR, CI confidence interval, ICU intensive care unit, DIC disseminated intravascular coagulation, MODS, multi-organ dysfunction syndrome, MV mechanical ventilation, OR odds ratio, uCysC urinary cystatin C, uCr urinary creatinine
  2. aIllness severity was assessed by the score for neonatal acute physiology in critically ill neonates and the pediatric risk of mortality III score in critically ill children
  3. bAdministered or developed during ICU stay
  4. cDeveloped during the first week after ICU admission. Severe AKI was defined as Kidney Disease: Improving Global Outcomes (KDIGO) stages 2 and 3
  5. dOdds ratio represents the increase in risk per 10,000 ng/mg increase in uCysC/uCr
  6. eAfter adjustment for illness severity
  7. fAfter adjustment for body weight
  8. gAfter adjustment for body weight and illness severity
  9. hAfter adjustment for body weight, illness severity, MV, and AKI stage