| OR | 95% CI | P value | AOR | 95% CI | P value |
---|
Body weight, kg | 1.00 | 0.97–1.03 | 0.968 | 0.99e | 0.95–1.02 | 0.454 |
Illness severitya, score | 1.14 | 1.09–1.19 | <0.001 | 1.14f | 1.09–1.20 | <0.001 |
MVb | 7.10 | 3.64–13.86 | <0.001 | 4.72g | 2.28–9.76 | <0.001 |
MV duration, days | 1.09 | 1.05–1.12 | <0.001 | 1.07g | 1.04–1.11 | <0.001 |
AKIc | 3.17 | 1.64–6.10 | 0.001 | 2.09g | 0.94–-3.97 | 0.049 |
AKI stage | 1.87 | 1.34–2.60 | <0.001 | 1.49g | 1.00–4.33 | 0.031 |
Severe AKIc | 3.72 | 1.63–8.46 | 0.002 | 2.25g | 0.91–5.57 | 0.079 |
Sepsisb | 3.17 | 1.62–6.18 | 0.001 | 2.58h | 1.22–5.45 | 0.013 |
Shock/DICb | 2.44 | 1.22–4.87 | 0.011 | 1.32h | 0.59–2.96 | 0.500 |
MODSb | 2.52 | 1.28–4.94 | 0.007 | 1.18h | 0.51–2.72 | 0.706 |
Furosemideb | 2.67 | 1.46–4.87 | 0.001 | 1.09h | 0.53–2.23 | 0.814 |
Initial uCysC, ng/mg uCr | 1.19d | 1.08–1.33 | 0.001 | 1.13d, h | 1.01–1.26 | 0.041 |
Peak uCysC, ng/mg uCr | 1.26d | 1.16–1.38 | <0.001 | 1.17d, h | 1.07–1.28 | <0.001 |
- AKI acute kidney injury, AOR adjusted OR, CI confidence interval, ICU intensive care unit, DIC disseminated intravascular coagulation, MODS, multi-organ dysfunction syndrome, MV mechanical ventilation, OR odds ratio, uCysC urinary cystatin C, uCr urinary creatinine
- aIllness severity was assessed by the score for neonatal acute physiology in critically ill neonates and the pediatric risk of mortality III score in critically ill children
- bAdministered or developed during ICU stay
- cDeveloped during the first week after ICU admission. Severe AKI was defined as Kidney Disease: Improving Global Outcomes (KDIGO) stages 2 and 3
- dOdds ratio represents the increase in risk per 10,000 ng/mg increase in uCysC/uCr
- eAfter adjustment for illness severity
- fAfter adjustment for body weight
- gAfter adjustment for body weight and illness severity
- hAfter adjustment for body weight, illness severity, MV, and AKI stage