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Table 5 Predictive characteristics of urinary cystatin C for AKI or severe AKI (n = 510)

From: Subclinical acute kidney injury is associated with adverse outcomes in critically ill neonates and children

uCysC, ng/mg uCr

AUC

95% CI

P value

Optimal cutoff value

Sensitivity

Specificity

LR+

LR-

AKI

 Initial uCysC

0.64

0.57–0.71

<0.001

1788.0

38.0%

85.2%

2.6

0.73

 Peak uCysC

0.63

0.56–0.70

<0.001

8816.0

30.4%

93.3%

4.5

0.75

Severe AKI

 Initial uCysC

0.72

0.63–0.82

<0.001

3389.0

50.0%

89.1%

4.6

0.56

 Peak uCysC

0.72

0.63–0.81

<0.001

1736.0

61.1%

76.0%

2.5

0.51

  1. AKI acute kidney injury, AUC the area under the ROC curve, CI confidence interval, LR+ positive likelihood ratio, LR- negative likelihood ratio, uCysC urinary cystatin C
  2. AKI developed during the first week after ICU admission. Kidney Disease: Improving Global Outcomes (KDIGO) stage 2 or 3 was defined as severe AKI