|
uCysC, ng/mg uCr
|
AUC
|
95% CI
|
P value
|
Optimal cutoff value
|
Sensitivity
|
Specificity
|
LR+
|
LR-
|
|---|
|
AKI
|
|
Initial uCysC
|
0.64
|
0.57–0.71
|
<0.001
|
1788.0
|
38.0%
|
85.2%
|
2.6
|
0.73
|
|
Peak uCysC
|
0.63
|
0.56–0.70
|
<0.001
|
8816.0
|
30.4%
|
93.3%
|
4.5
|
0.75
|
|
Severe AKI
|
|
Initial uCysC
|
0.72
|
0.63–0.82
|
<0.001
|
3389.0
|
50.0%
|
89.1%
|
4.6
|
0.56
|
|
Peak uCysC
|
0.72
|
0.63–0.81
|
<0.001
|
1736.0
|
61.1%
|
76.0%
|
2.5
|
0.51
|
- AKI acute kidney injury, AUC the area under the ROC curve, CI confidence interval, LR+ positive likelihood ratio, LR- negative likelihood ratio, uCysC urinary cystatin C
- AKI developed during the first week after ICU admission. Kidney Disease: Improving Global Outcomes (KDIGO) stage 2 or 3 was defined as severe AKI
