Skip to main content

Table 5 Predictive characteristics of urinary cystatin C for AKI or severe AKI (n = 510)

From: Subclinical acute kidney injury is associated with adverse outcomes in critically ill neonates and children

uCysC, ng/mg uCr AUC 95% CI P value Optimal cutoff value Sensitivity Specificity LR+ LR-
AKI
 Initial uCysC 0.64 0.57–0.71 <0.001 1788.0 38.0% 85.2% 2.6 0.73
 Peak uCysC 0.63 0.56–0.70 <0.001 8816.0 30.4% 93.3% 4.5 0.75
Severe AKI
 Initial uCysC 0.72 0.63–0.82 <0.001 3389.0 50.0% 89.1% 4.6 0.56
 Peak uCysC 0.72 0.63–0.81 <0.001 1736.0 61.1% 76.0% 2.5 0.51
  1. AKI acute kidney injury, AUC the area under the ROC curve, CI confidence interval, LR+ positive likelihood ratio, LR- negative likelihood ratio, uCysC urinary cystatin C
  2. AKI developed during the first week after ICU admission. Kidney Disease: Improving Global Outcomes (KDIGO) stage 2 or 3 was defined as severe AKI