|
OR
|
95% CI
|
P value
|
AOR
|
95% CI
|
P value
|
---|
Age, months
|
1.01
|
1.00–1.01
|
0.001
|
1.00d
|
0.98–1.01
|
0.592
|
Body weight, kg
|
1.04
|
1.02–1.06
|
<0.001
|
1.06e
|
0.99–1.13
|
0.123
|
Illness severitya, score
|
1.12
|
1.07–1.16
|
<0.001
|
1.11f
|
1.06–1.16
|
<0.001
|
MVb
|
3.13
|
1.92–5.12
|
<0.001
|
2.02g
|
1.16–3.51
|
0.013
|
MV duration, days
|
1.05
|
1.02–1.08
|
0.002
|
1.02h
|
0.98–1.06
|
0.292
|
Shock/DICb
|
2.81
|
1.59–4.98
|
<0.001
|
1.84h
|
0.98–3.44
|
0.058
|
MODSb
|
3.50
|
2.02–6.07
|
<0.001
|
1.87h
|
0.99–3.51
|
0.053
|
Furosemideb
|
3.85
|
2.35–6.32
|
<0.001
|
2.84h
|
1.62–4.98
|
<0.001
|
Steroidb
|
1.84
|
1.13–2.99
|
0.015
|
1.07h
|
0.60–1.91
|
0.821
|
Initial uCysC, ng/mg uCr
|
1.18c
|
1.07–1.31
|
0.001
|
1.12c, h
|
1.02–1.23
|
0.024
|
Peak uCysC, ng/mg uCr
|
1.18c
|
1.09–1.28
|
<0.001
|
1.11c, h
|
1.02–1.21
|
0.014
|
- AKI acute kidney injury, AOR adjusted OR, CI confidence interval, DIC disseminated intravascular coagulation, ICU intensive care unit, MODS multi-organ dysfunction syndrome, MV mechanical ventilation, OR odds ratio, uCysC urinary cystatin C, uCr urinary creatinine
- aIllness severity was assessed by the score for neonatal acute physiology in critically ill neonates and the pediatric risk of mortality III score in critically ill children
- bAdministered or developed during ICU stay
- cOdds ratio represents the increase in risk per 10,000 ng/mg increase in uCysC/uCr
- dAfter adjustment for body weight and illness severity
- eAfter adjustment for age and illness severity
- fAfter adjustment for age and body weight
- gAfter adjustment for age, body weight, and illness severity
- hAfter adjustment for age, body weight, illness severity, and mechanical ventilation