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Table 4 Association between urinary cystatin C or clinical variables and AKI that developed during the first week after ICU admission (n = 510)

From: Subclinical acute kidney injury is associated with adverse outcomes in critically ill neonates and children

  OR 95% CI P value AOR 95% CI P value
Age, months 1.01 1.00–1.01 0.001 1.00d 0.98–1.01 0.592
Body weight, kg 1.04 1.02–1.06 <0.001 1.06e 0.99–1.13 0.123
Illness severitya, score 1.12 1.07–1.16 <0.001 1.11f 1.06–1.16 <0.001
MVb 3.13 1.92–5.12 <0.001 2.02g 1.16–3.51 0.013
MV duration, days 1.05 1.02–1.08 0.002 1.02h 0.98–1.06 0.292
Shock/DICb 2.81 1.59–4.98 <0.001 1.84h 0.98–3.44 0.058
MODSb 3.50 2.02–6.07 <0.001 1.87h 0.99–3.51 0.053
Furosemideb 3.85 2.35–6.32 <0.001 2.84h 1.62–4.98 <0.001
Steroidb 1.84 1.13–2.99 0.015 1.07h 0.60–1.91 0.821
Initial uCysC, ng/mg uCr 1.18c 1.07–1.31 0.001 1.12c, h 1.02–1.23 0.024
Peak uCysC, ng/mg uCr 1.18c 1.09–1.28 <0.001 1.11c, h 1.02–1.21 0.014
  1. AKI acute kidney injury, AOR adjusted OR, CI confidence interval, DIC disseminated intravascular coagulation, ICU intensive care unit, MODS multi-organ dysfunction syndrome, MV mechanical ventilation, OR odds ratio, uCysC urinary cystatin C, uCr urinary creatinine
  2. aIllness severity was assessed by the score for neonatal acute physiology in critically ill neonates and the pediatric risk of mortality III score in critically ill children
  3. bAdministered or developed during ICU stay
  4. cOdds ratio represents the increase in risk per 10,000 ng/mg increase in uCysC/uCr
  5. dAfter adjustment for body weight and illness severity
  6. eAfter adjustment for age and illness severity
  7. fAfter adjustment for age and body weight
  8. gAfter adjustment for age, body weight, and illness severity
  9. hAfter adjustment for age, body weight, illness severity, and mechanical ventilation
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Critical Care

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