| OR | 95% CI | P value | AOR | 95% CI | P value |
---|
Age, months | 1.01 | 1.00–1.01 | 0.001 | 1.00d | 0.98–1.01 | 0.592 |
Body weight, kg | 1.04 | 1.02–1.06 | <0.001 | 1.06e | 0.99–1.13 | 0.123 |
Illness severitya, score | 1.12 | 1.07–1.16 | <0.001 | 1.11f | 1.06–1.16 | <0.001 |
MVb | 3.13 | 1.92–5.12 | <0.001 | 2.02g | 1.16–3.51 | 0.013 |
MV duration, days | 1.05 | 1.02–1.08 | 0.002 | 1.02h | 0.98–1.06 | 0.292 |
Shock/DICb | 2.81 | 1.59–4.98 | <0.001 | 1.84h | 0.98–3.44 | 0.058 |
MODSb | 3.50 | 2.02–6.07 | <0.001 | 1.87h | 0.99–3.51 | 0.053 |
Furosemideb | 3.85 | 2.35–6.32 | <0.001 | 2.84h | 1.62–4.98 | <0.001 |
Steroidb | 1.84 | 1.13–2.99 | 0.015 | 1.07h | 0.60–1.91 | 0.821 |
Initial uCysC, ng/mg uCr | 1.18c | 1.07–1.31 | 0.001 | 1.12c, h | 1.02–1.23 | 0.024 |
Peak uCysC, ng/mg uCr | 1.18c | 1.09–1.28 | <0.001 | 1.11c, h | 1.02–1.21 | 0.014 |
- AKI acute kidney injury, AOR adjusted OR, CI confidence interval, DIC disseminated intravascular coagulation, ICU intensive care unit, MODS multi-organ dysfunction syndrome, MV mechanical ventilation, OR odds ratio, uCysC urinary cystatin C, uCr urinary creatinine
- aIllness severity was assessed by the score for neonatal acute physiology in critically ill neonates and the pediatric risk of mortality III score in critically ill children
- bAdministered or developed during ICU stay
- cOdds ratio represents the increase in risk per 10,000 ng/mg increase in uCysC/uCr
- dAfter adjustment for body weight and illness severity
- eAfter adjustment for age and illness severity
- fAfter adjustment for age and body weight
- gAfter adjustment for age, body weight, and illness severity
- hAfter adjustment for age, body weight, illness severity, and mechanical ventilation