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Table 4 Association between urinary cystatin C or clinical variables and AKI that developed during the first week after ICU admission (n = 510)

From: Subclinical acute kidney injury is associated with adverse outcomes in critically ill neonates and children

 

OR

95% CI

P value

AOR

95% CI

P value

Age, months

1.01

1.00–1.01

0.001

1.00d

0.98–1.01

0.592

Body weight, kg

1.04

1.02–1.06

<0.001

1.06e

0.99–1.13

0.123

Illness severitya, score

1.12

1.07–1.16

<0.001

1.11f

1.06–1.16

<0.001

MVb

3.13

1.92–5.12

<0.001

2.02g

1.16–3.51

0.013

MV duration, days

1.05

1.02–1.08

0.002

1.02h

0.98–1.06

0.292

Shock/DICb

2.81

1.59–4.98

<0.001

1.84h

0.98–3.44

0.058

MODSb

3.50

2.02–6.07

<0.001

1.87h

0.99–3.51

0.053

Furosemideb

3.85

2.35–6.32

<0.001

2.84h

1.62–4.98

<0.001

Steroidb

1.84

1.13–2.99

0.015

1.07h

0.60–1.91

0.821

Initial uCysC, ng/mg uCr

1.18c

1.07–1.31

0.001

1.12c, h

1.02–1.23

0.024

Peak uCysC, ng/mg uCr

1.18c

1.09–1.28

<0.001

1.11c, h

1.02–1.21

0.014

  1. AKI acute kidney injury, AOR adjusted OR, CI confidence interval, DIC disseminated intravascular coagulation, ICU intensive care unit, MODS multi-organ dysfunction syndrome, MV mechanical ventilation, OR odds ratio, uCysC urinary cystatin C, uCr urinary creatinine
  2. aIllness severity was assessed by the score for neonatal acute physiology in critically ill neonates and the pediatric risk of mortality III score in critically ill children
  3. bAdministered or developed during ICU stay
  4. cOdds ratio represents the increase in risk per 10,000 ng/mg increase in uCysC/uCr
  5. dAfter adjustment for body weight and illness severity
  6. eAfter adjustment for age and illness severity
  7. fAfter adjustment for age and body weight
  8. gAfter adjustment for age, body weight, and illness severity
  9. hAfter adjustment for age, body weight, illness severity, and mechanical ventilation