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Table 2 Spearman’s analysis of correlation between urinary cystatin C and clinical variables (n = 510)

From: Subclinical acute kidney injury is associated with adverse outcomes in critically ill neonates and children

  Initial urinary cystatin C Peak urinary cystatin C
Spearman’s r P value Spearman’s r P value
Age, months -0.230 <0.001 -0.307 <0.001
Body weight, kg -0.302 <0.001 -0.389 <0.001
Male, n -0.005 0.904 -0.024 0.589
Illness severitya, score 0.358 <0.001 0.415 <0.001
MVb, n 0.087 0.051 0.128 0.004
Duration of MV, days 0.093 0.035 0.141 0.001
AKIc, n 0.172 <0.001 0.164 <0.001
AKI stage 0.182 <0.001 0.175 <0.001
Severe AKId, n 0.197 <0.001 0.196 <0.001
Sepsisb, n 0.040 0.362 0.065 0.141
Shock/DICb, n 0.060 0.173 0.076 0.086
MODSb, n 0.102 0.021 0.122 0.006
Furosemideb, n 0.070 0.112 0.127 0.004
Steroidb, n -0.020 0.655 -0.005 0.919
Antibioticsb, n 0.080 0.072 0.106 0.017
Vancomycinb, n 0.106 0.016 0.121 0.006
Mannitolb, n -0.041 0.350 -0.070 0.112
Inotropeb, n 0.023 0.606 0.034 0.444
Hemofiltrationb, n 0.007 0.880 -0.006 0.898
  1. r = Spearman’s correlation coefficient
  2. AKI acute kidney injury, DIC disseminated intravascular coagulation, ICU intensive care unit, MODS multi-organ dysfunction syndrome, MV mechanical ventilation
  3. aIllness severity was assessed by the score for neonatal acute physiology in critically ill neonates and the pediatric risk of mortality III score in critically ill children
  4. bAdministered or developed during ICU stay
  5. cDeveloped during the first week after ICU admission
  6. dSevere AKI was defined as Kidney Disease: Improving Global Outcomes (KDIGO) stages 2 and 3