| |
Survivors, n = 462
|
Non-survivors, n = 48
|
P value
|
|---|
|
Age, months
|
1.37 [0.33–16.0]
|
0.97 [0.33–13.5]
|
0.540
|
|
Age group, n
| | | |
|
≤ 28 days, n = 239
|
215 (46.5)
|
24 (50.0)
|
0.893
|
|
≤ 1 year, n = 132
|
120 (26.0)
|
12 (25.0)
|
|
> 1 year, n = 139
|
127 (27.5)
|
12 (25.0)
|
|
Body weight, kg
|
4.2 [2.5–11.0]
|
2.9 [1.5–10.0]
|
0.035
|
|
Male, n
|
277 (60.0)
|
27 (56.3)
|
0.645
|
|
Illness severitya, score
|
6 [3–9]
|
10 [6–14]
|
<0.001
|
|
Diagnosis on ICU admission
|
|
Respiratory diseases, n
|
176 (38.1)
|
10 (20.8)
|
0.054
|
|
Neurologic diseases, n
|
59 (12.8)
|
1 (2.1)
|
|
Preterm/LBW, n
|
37 (8.0)
|
5 (10.4)
|
|
Sepsis, n
|
45 (9.7)
|
11 (22.9)
|
|
Poison/trauma/accident, n
|
34 (7.4)
|
5 (10.4)
|
|
Cardiologic diseases, n
|
20 (4.3)
|
1 (2.1)
|
|
Gastroenterologic, n
|
19 (4.1)
|
0 (0)
|
|
Hematologic diseases, n
|
17 (3.7)
|
6 (12.5)
|
|
MVb, n
|
127 (27.5)
|
35 (72.9)
|
<0.001
|
|
MV duration, days
|
0 [0–0.84]
|
2.23 [0–6.86]
|
<0.001
|
|
MV duration ≥ 48 hours, n
|
89 (19.3)
|
24 (50.0)
|
<0.001
|
|
AKIc, n
|
63 (13.6)
|
16 (33.3)
|
0.002
|
|
AKI stage 1, n
|
36 (7.8)
|
7 (14.6)
|
<0.001
|
|
AKI stage 2, n
|
19 (4.1)
|
5 (10.4)
|
|
AKI stage 3, n
|
8 (1.7)
|
4 (8.3)
|
|
Sepsisb, n
|
58 (9.7)
|
15 (22.9)
|
0.001
|
|
Shock/DICb, n
|
61 (13.2)
|
13 (27.1)
|
0.013
|
|
MODSb, n
|
65 (14.1)
|
14 (29.2)
|
0.009
|
|
Furosemideb, n
|
126 (27.3)
|
24 (50.0)
|
0.002
|
|
Steroidb, n
|
150 (32.5)
|
21 (43.8)
|
0.147
|
|
Antibioticsb, n
|
418 (90.5)
|
46 (95.8)
|
0.294
|
|
Vancomycinb, n
|
35 (7.6)
|
7 (14.6)
|
0.099
|
|
Mannitolb, n
|
115 (24.9)
|
16 (33.3)
|
0.225
|
|
Inotropeb, n
|
60 (13.0)
|
10 (20.8)
|
0.182
|
|
Hemofiltrationb, n
|
15 (3.2)
|
3 (6.3)
|
0.235
|
|
Initial uCysC, ng/mg uCr
|
311.82 [122.22–975.34]
|
1587.39 [583.19–8749.16]
|
<0.001
|
|
Peak uCysC, ng/mg uCr
|
426.49 [165.23–1607.62]
|
7026.73 [1285.25–33879.56]
|
<0.001
|
- Values are median [interquartile range] or number (percentage)
- AKI acute kidney injury, DIC disseminated intravascular coagulation, ICU intensive care unit, LBW low birth weight, MODS multi-organ dysfunction syndrome, MV mechanical ventilation, uCysC urinary cystatin C, uCr urinary creatinine
- aIllness severity was assessed by the score for neonatal acute physiology in critically ill neonates and the pediatric risk of mortality III score in critically ill children
- bAdministered or developed during ICU stay
- cDeveloped during the first week after ICU admission
